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By following more than 1000 individuals with clinically isolated syndrome for an average of 81 months, Tintoré et al. examine the factors that predict conversion to multiple sclerosis and accumulation of disability.
 
Vuono et al. reveal tau oligomers and hyperphosphorylated tau aggregates in post-mortem Huntington’s disease brains, including those of young-onset cases, and show that tau haplotypes influence cognitive decline.
 
Kinghorn et al. provide insights into the mechanisms by which altered activity of the phospholipase PLA2G6 could contribute to neurodegenerative disorders,  including early-onset dystonia-parkinsonism.
 
 

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2014 Impact Factor: 9.196
 
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