Brain, Vol. 106, No. 2, 257-270, 1983
© 1983 Oxford University Press
research-article |
COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSON'S DISEASE
From the The National Hospital for Nervous Diseases Maida Vale, London W9 2TL
Neuropsychological tests known to reveal abnormalities in patients with frontal lobe damage were used to explore cognitive function in 30 mildly disabled, right-handed patients with idiopathic Parkinson's disease. None of the patients had received treatment and all had normal CT brain scans. Patients with depression or high ischaemia scores were excluded from the study and similar selection criteria were used for the age-matched controls. No impairment of general intellectual function was found in the patients using the WAIS and New Adult Reading IQ tests and no abnormalities were apparent on cognitive estimates and two-choice Recognition Memory Tests. Patients with Parkinson's disease, however, had significantly greater difficulty in shifting conceptual sets and produced more perseverative errors on both the modified Wisconsin Card Sorting Test and Benton's Word Fluency Test. These subtle cognitive difficulties might underlie the mental inflexibility and rigidity of Parkinson's disease and could be attributed to destruction of the ascending dopaminergic meso-corticolimbic pathway
Received June 17, 1982.
Revised October 19, 1982.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Gattellaro, L. Minati, M. Grisoli, C. Mariani, F. Carella, M. Osio, E. Ciceri, A. Albanese, and M.G. Bruzzone White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): 1222 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Marklund, A. Larsson, E. Elgh, J. Linder, K. A. Riklund, L. Forsgren, and L. Nyberg Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease: transient caudate abnormalities during updating of working memory Brain, February 1, 2009; 132(2): 336 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marighetto, S. Valerio, J. Philippin, V. Bertaina-Anglade, C. Drieu la Rochelle, R. Jaffard, and P. Morain Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodents J Psychopharmacol, July 1, 2008; 22(5): 511 - 521. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Nagano-Saito, M. Leyton, O. Monchi, Y. K. Goldberg, Y. He, and A. Dagher Dopamine Depletion Impairs Frontostriatal Functional Connectivity during a Set-Shifting Task J. Neurosci., April 2, 2008; 28(14): 3697 - 3706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. SHAGAM Unlocking the Secrets Of Parkinson Disease Radiol. Technol., January 1, 2008; 79(3): 227 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Muslimovic, B. Post, J. D. Speelman, and B. Schmand Cognitive profile of patients with newly diagnosed Parkinson disease Neurology, October 25, 2005; 65(8): 1239 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Fantini, L. Ferini-Strambi, and J. Montplaisir Idiopathic REM sleep behavior disorder: Toward a better nosologic definition Neurology, March 8, 2005; 64(5): 780 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Foltynie, C. E. G. Brayne, T. W. Robbins, and R. A. Barker The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study Brain, March 1, 2004; 127(3): 550 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ferini-Strambi, M. R. Di Gioia, V. Castronovo, A. Oldani, M. Zucconi, and S. F. Cappa Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): Does the idiopathic form of RBD really exist? Neurology, January 13, 2004; 62(1): 41 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. G. Lewis, A. Dove, T. W. Robbins, R. A. Barker, and A. M. Owen Cognitive Impairments in Early Parkinson's Disease Are Accompanied by Reductions in Activity in Frontostriatal Neural Circuitry J. Neurosci., July 16, 2003; 23(15): 6351 - 6356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Schneider, J. P. Tinker, F. Menzaghi, and G. K. Lloyd The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys J. Pharmacol. Exp. Ther., July 1, 2003; 306(1): 401 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Feigin, M. F. Ghilardi, M. Carbon, C. Edwards, M. Fukuda, V. Dhawan, C. Margouleff, C. Ghez, and D. Eidelberg Effects of levodopa on motor sequence learning in Parkinson's disease Neurology, June 10, 2003; 60(11): 1744 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, R. A. Barker, B. J. Sahakian, and T. W. Robbins Mechanisms of cognitive set flexibility in Parkinson's disease Brain, December 1, 2001; 124(12): 2503 - 2512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.S. Crofts, J.W. Dalley, P. Collins, J.C.M. Van Denderen, B.J. Everitt, T.W. Robbins, and A.C. Roberts Differential Effects of 6-OHDA Lesions of the Frontal Cortex and Caudate Nucleus on the Ability to Acquire an Attentional Set Cereb Cortex, November 1, 2001; 11(11): 1015 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Monchi, M. Petrides, V. Petre, K. Worsley, and A. Dagher Wisconsin Card Sorting Revisited: Distinct Neural Circuits Participating in Different Stages of the Task Identified by Event-Related Functional Magnetic Resonance Imaging J. Neurosci., October 1, 2001; 21(19): 7733 - 7741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Olanow, R. L. Watts, and W. C. Koller An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment Neurology, June 12, 2001; 56(suppl_5): S1 - S88. [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Slaughter, K. A. Slaughter, D. Nichols, S. E. Holmes, and M. P. Martens Prevalence, Clinical Manifestations, Etiology, and Treatment of Depression in Parkinson's Disease J Neuropsychiatry Clin Neurosci, May 1, 2001; 13(2): 187 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dujardin, L. Defebvre, C. Grunberg, E. Becquet, and A. Destee Memory and executive function in sporadic and familial Parkinson's disease Brain, February 1, 2001; 124(2): 389 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Graham, M. N. J. Paley, R. A. Grunewald, N. Hoggard, and P. D. Griffiths Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence Brain, December 1, 2000; 123(12): 2423 - 2431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Soliveri, D. Monza, D. Paridi, F. Carella, S. Genitrini, D. Testa, and F. Girotti Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy J. Neurol. Neurosurg. Psychiatry, September 1, 2000; 69(3): 313 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Portin, S. Laatu, A. Revonsuo, and U. K. Rinne Impairment of Semantic Knowledge in Parkinson Disease Arch Neurol, September 1, 2000; 57(9): 1338 - 1343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. O. Rinne, R. Portin, H. Ruottinen, E. Nurmi, J. Bergman, M. Haaparanta, and O. Solin Cognitive Impairment and the Brain Dopaminergic System in Parkinson Disease: [18F]Fluorodopa Positron Emission Tomographic Study Arch Neurol, April 1, 2000; 57(4): 470 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. M. Hu, S. D. Taylor-Robinson, K. R. Chaudhuri, J. D. Bell, C. Labbe, V. J. Cunningham, M. J. Koepp, A. Hammers, R. G. Morris, N. Turjanski, et al. Cortical dysfunction in non-demented Parkinson's disease patients: A combined 31P-MRS and 18FDG-PET study Brain, February 1, 2000; 123(2): 340 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Brown, A. A. Rahill, J. M. Gorell, C. McDonald, S. J. Brown, M. Sillanpaa, and C. Shults Validity of the Dementia Rating Scale in Assessing Cognitive Function in Parkinson's Disease J Geriatr Psychiatry Neurol, December 1, 1999; 12(4): 180 - 188. [Abstract] [PDF]
|
|
|
|
|
|
M. K. York, H. S. Levin, R. G. Grossman, and W. J. Hamilton Neuropsychological outcome following unilateral pallidotomy Brain, December 1, 1999; 122(12): 2209 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dujardin, A. Duhamel, E. Becquet, C. Grunberg, L. Defebvre, and A. Destee Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease J. Neurol. Neurosurg. Psychiatry, September 1, 1999; 67(3): 323 - 328. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Schneider, J. P. Tinker, M. Van Velson, F. Menzaghi, and G. K. Lloyd Nicotinic Acetylcholine Receptor Agonist SIB-1508Y Improves Cognitive Functioning in Chronic Low-Dose MPTP-Treated Monkeys J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 731 - 739. [Abstract] [Full Text]
|
|
|
|
|
|
M T M Hu, S D Taylor-Robinson, K R. Chaudhuri, J D Bell, R G Morris, C Clough, D J Brooks, and N Turjanski Evidence for cortical dysfunction in clinically non-demented patients with Parkinson's disease: a proton MR spectroscopy study J. Neurol. Neurosurg. Psychiatry, July 1, 1999; 67(1): 20 - 26. [Abstract] [Full Text]
|
|
|
|
|
|
F. Mahieux, G. Fenelon, A. Flahault, M.-J. Manifacier, D. Michelet, and F. Boller Neuropsychological prediction of dementia in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, February 1, 1998; 64(2): 178 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Levy, H. R. Friedman, L. Davachi, and P. S. Goldman-Rakic Differential Activation of the Caudate Nucleus in Primates Performing Spatial and Nonspatial Working Memory Tasks J. Neurosci., May 15, 1997; 17(10): 3870 - 3882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Knowlton, J. A. Mangels, and L. R. Squire A Neostriatal Habit Learning System in Humans Science, September 6, 1996; 273(5280): 1399 - 1402. [Abstract]
|
|
|
|
 |
|
 A. K. Afifi Topical Review: Basal Ganglia: Functional Anatomy and Physiology. Part 2 J Child Neurol, October 1, 1994; 9(4): 352 - 361. [Abstract] [PDF]
|
|
|
|
|
|
I. Appollonio, J. Grafman, K. Clark, P. Nichelli, T. Zeffiro, and M. Hallett Implicit and Explicit Memory in Patients With Parkinson's Disease With and Without Dementia Arch Neurol, April 1, 1994; 51(4): 359 - 367. [Abstract] [PDF]
|
|
|
|
|
|
Y. Stern, M. Richards, M. Sano, and R. Mayeux Comparison of Cognitive Changes in Patients With Alzheimer's and Parkinson's Disease Arch Neurol, October 1, 1993; 50(10): 1040 - 1045. [Abstract] [PDF]
|
|
|
|
|
|
W. W. Beatty and N. Monson Picture and Motor Sequencing in Parkinson's Disease J Geriatr Psychiatry Neurol, October 1, 1990; 3(4): 192 - 197. [Abstract] [PDF]
|
|
|
|
|
|
W. W. Beatty and N. Monson Problem Solving in Parkinson's Disease: Comparison of Performance on the Wisconsin and California Card Sorting Tests J Geriatr Psychiatry Neurol, July 1, 1990; 3(3): 163 - 171. [Abstract] [PDF]
|
|
|
|
|
|
N. Wolfe, R. Linn, V. L. Babikian, J. E. Knoefel, and M. L. Albert Frontal Systems Impairment Following Multiple Lacunar Infarcts Arch Neurol, February 1, 1990; 47(2): 129 - 132. [Abstract] [PDF]
|
|
|
|
|
|
H. C. Chui Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships Arch Neurol, July 1, 1989; 46(7): 806 - 814. [Abstract] [PDF]
|
|
|
|
|
|
W. W. Beatty, R. D. Staton, W. S. Weir, N. Monson, and H. A. Whitaker Cognitive Disturbances in Parkinson's Disease J Geriatr Psychiatry Neurol, January 1, 1989; 2(1): 22 - 33. [Abstract] [PDF]
|
|
|
|
|
|
B. Dubois, B. Pillon, F. Legault, Y. Agid, and F. Lhermitte Slowing of Cognitive Processing in Progressive Supranuclear Palsy: A Comparison With Parkinson's Disease Arch Neurol, November 1, 1988; 45(11): 1194 - 1199. [Abstract] [PDF]
|
|
|
|
|
|
D. G. Lichter, A. J. Corbett, G. M. Fitzgibbon, O. R. Davidson, J. K. A. Hope, G. V. Goddard, K. J. Sharpies, and M. Pollock Cognitive and Motor Dysfunction in Parkinson's Disease: Clinical, Performance, and Computed Tomographic Correlations Arch Neurol, August 1, 1988; 45(8): 854 - 860. [Abstract] [PDF]
|
|
|
|
|
|
J. L. Cummings Intellectual Impairment in Parkinson's Disease: Clinical, Pathologic, and Biochemical Correlates J Geriatr Psychiatry Neurol, January 1, 1988; 1(1): 24 - 36. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Pentland, T. K Pitcairn, J. M Gray, and W. Riddle Jr. The effects of reduced expression in Parkinson's disease on impression formation by health professionals Clinical Rehabilitation, November 1, 1987; 1(4): 307 - 312. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Nanton The Consequences of Parkinson's Disease - Needs, Provisions and Initiatives Perspectives in Public Health, April 1, 1985; 105(2): 52 - 54.
|
|
|
|
|
|
J. L. Cummings and D. F. Benson Subcortical Dementia: Review of an Emerging Concept Arch Neurol, August 1, 1984; 41(8): 874 - 879. [Abstract] [PDF]
|
|