Brain, Vol. 107, No. 2, 447-461, 1984
© 1984 Oxford University Press
research-article |
REGIONAL CEREBRAL BLOOD FLOW DURING MIGRAINE ATTACKS BY XENON-133 INHALATION AND EMISSION TOMOGRAPHY*
1Department of Neurology, Rigshospitalet, Gentofte Hospital Copenhagen, Denmark 2Department of Medical Physiology A, The Panum Institute, Gentofte Hospital Copenhagen, Denmark 3Department of Neurology Gentofte Hospital, Copenhagen, Denmark
Correspondence to:
Correspondence to Dr Martin Lauritzen, Institute of Medical Physicology, Department A, University of Copenhagen, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
Regional cerebral blood flow (rCBF) was measured by single photon emission tomography, using Xenon-133 inhalation during migraine attacks. The method yields images of three brain slices, depicting rCBF with a spatial resolution of 1.7 cm. Twelve patients with common migraine showed a normal cerebral blood flow pattern during an attack. Of 11 patients with classical migraine, 8 displayed a unilateral region of hypoperfusion, while 3 had a normal flow pattern. The focal decrease of blood flow averaged 17 per cent as compared with the symmetrical contralateral region. The localization of the blood flow reduction corresponded to the tomographic representation of the lateral aspect of the cortex in 8 patients, while in one patient the mesial aspect also appeared to be involved. The low-flow regions were always on the side opposite to the focal neurological symptoms. The hypoperfusion remained through the headache period for four to six hours. Regions of relative or absolute hyperaemia were not observed during headache of either form of migraine. Between attacks, rCBF was normal except in one patient who had a minor low-flow region in the insula.
The cortical distribution of the vasomotor changes in classical migraine appeared unrelated to the distribution of major cerebral arteries and may represent a manifestation of disturbed cerebral metabolism, possibly the spreading depression of Leão. Since classical migraine in most cases was associated with intracranial blood flow changes while common migraine was not, the study was taken to support that these two forms of migraine may differ, not only on a clinical basis, but also on pathophysiological grounds.
.
Received May 24, 1983. Revised August 2, 1983.
* Part of this work has been presented at the 24th Scandinavian Congress of Neurology (Olesen and Lauritzen, 1982).
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Funke, M. Kron, M. Dutschmann, and M. Muller Infant Brain Stem Is Prone to the Generation of Spreading Depression During Severe Hypoxia J Neurophysiol, May 1, 2009; 101(5): 2395 - 2410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.S Fokas, A Iserles, and V Marinakis Reconstruction algorithm for single photon emission computed tomography and its numerical implementation J R Soc Interface, February 22, 2006; 3(6): 45 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.A.G. Teive, P. A. Kowacs, P. M. Filho, E. J. Piovesan, and L. C. Werneck Leao's cortical spreading depression: From experimental "artifact" to physiological principle Neurology, November 8, 2005; 65(9): 1455 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Stang, A. P. Carson, K. M. Rose, J. Mo, S. A. Ephross, E. Shahar, and M. Szklo Headache, cerebrovascular symptoms, and stroke: The Atherosclerosis Risk in Communities Study Neurology, May 10, 2005; 64(9): 1573 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. May Headache: lessons learned from functional imaging Br. Med. Bull., March 1, 2003; 65(1): 223 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Strong, M. Fabricius, M. G. Boutelle, S. J. Hibbins, S. E. Hopwood, R. Jones, M. C. Parkin, and M. Lauritzen Spreading and Synchronous Depressions of Cortical Activity in Acutely Injured Human Brain Stroke, December 1, 2002; 33(12): 2738 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Ba, M. Guiou, N. Pouratian, A. Muthialu, D. E. Rex, A. F. Cannestra, J. W. Y. Chen, and A. W. Toga Multiwavelength Optical Intrinsic Signal Imaging of Cortical Spreading Depression J Neurophysiol, November 1, 2002; 88(5): 2726 - 2735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Somjen Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization Physiol Rev, July 1, 2001; 81(3): 1065 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hadjikhani, M. Sanchez del Rio, O. Wu, D. Schwartz, D. Bakker, B. Fischl, K. K. Kwong, F. M. Cutrer, B. R. Rosen, R. B. H. Tootell, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex PNAS, March 29, 2001; (2001) 71582498. [Abstract] [Full Text]
|
|
|
|
|
|
D. C. Chugani, K. Niimura, S. Chaturvedi, O. Muzik, M. Fakhouri, M.-L. Lee, and H. T. Chugani Increased brain serotonin synthesis in migraine Neurology, October 22, 1999; 53(7): 1473 - 1473. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. E. Buring, P. Hebert, J. Romero, A. Kittross, Nancy, J. Manson, R. Peto, and C. Hennekens Migraine and Subsequent Risk of Stroke in the Physicians' Health Study Arch Neurol, February 1, 1995; 52(2): 129 - 134. [Abstract] [PDF]
|
|
|
|
|
|
M. D. Ferrari, J. Haan, J. A. K. Blokland, J. W. Arndt, P. Minnee, A. H. Zwinderman, E. K. J. Pauwels, and P. R. Saxena Cerebral Blood Flow During Migraine Attacks Without Aura and Effect of Sumatriptan Arch Neurol, February 1, 1995; 52(2): 135 - 139. [Abstract] [PDF]
|
|
|
|
 |
|
 R. P. Woods, M. Iacoboni, and J. C. Mazziotta Bilateral Spreading Cerebral Hypoperfusion during Spontaneous Migraine Headache N. Engl. J. Med., December 22, 1994; 331(25): 1689 - 1692. [Full Text]
|
|
|
|
 |
|
 T. S. Olsen Migraine: still a vascular illness? Vascular Medicine, September 1, 1991; 2(2): 147 - 159. [PDF]
|
|
|
|
|
|
T. S. Olsen and L. Friberg Ischemia May Be the Primary Cause of Neurological Deficits in Classic Migraine-Reply Arch Neurol, February 1, 1990; 47(2): 125 - 127. [Abstract] [PDF]
|
|
|
|
|
|
A. Shuaib and V. C. Hachinski Migraine and the Risks From Angiography Arch Neurol, August 1, 1988; 45(8): 911 - 912. [Abstract] [PDF]
|
|
|
|
|
|
A. R. Andersen, L. Friberg, T. S. Olsen, and J. Olesen Delayed Hyperemia Following Hypoperfusion in Classic Migraine: Single Photon Emission Computed Tomographic Demonstration Arch Neurol, February 1, 1988; 45(2): 154 - 159. [Abstract] [PDF]
|
|
|
|
|
|
J. P. Broderick and J. W. Swanson Migraine-Related Strokes: Clinical Profile and Prognosis in 20 Patients Arch Neurol, August 1, 1987; 44(8): 868 - 871. [Abstract] [PDF]
|
|
|
|
|
|
J. Olesen The Ischemic Hypotheses of Migraine Arch Neurol, March 1, 1987; 44(3): 321 - 322. [Abstract] [PDF]
|
|
|
|
|
|
H. Sachs, A. Wolf, J. A. G. Russell, and D. R. Christman Effect of Reserpine on Regional Cerebral Glucose Metabolism jjss in Control and Migraine Subjects Arch Neurol, November 1, 1986; 43(11): 1117 - 1123. [Abstract] [PDF]
|
|
|
|
|
|
W. D. Hooker and N. H. Raskin Neuropsychologic Alterations in Classic and Common Migraine Arch Neurol, July 1, 1986; 43(7): 709 - 712. [Abstract] [PDF]
|
|
|
|
|
|
V. Hachinski Common and Classic Migraine: One or Two Entities? Arch Neurol, March 1, 1985; 42(3): 277 - 277. [Abstract] [PDF]
|
|
|
|
|
|
N. Hadjikhani, M. Sanchez del Rio, O. Wu, D. Schwartz, D. Bakker, B. Fischl, K. K. Kwong, F. M. Cutrer, B. R. Rosen, R. B. H. Tootell, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex PNAS, April 10, 2001; 98(8): 4687 - 4692. [Abstract] [Full Text] [PDF]
|
|