Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by YAO, J. K.
Right arrow Articles by LUDWIG, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by YAO, J. K.
Right arrow Articles by LUDWIG, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 107, No. 2, 597-603, 1984
© 1984 Oxford University Press

research-article

LIPID ABNORMALITIES OF XANTHOMATOUS NERVES

JEFFREY K. YAO1, PETER JAMES DYCK, KEVIN P. CANNON and JURGEN LUDWIG{dagger}

The Peripheral Nerve Center, Section of Medical Pathology Mayo Clinic and Foundation Rochester, Minnesota 55905, USA {dagger}Department of Pathology, Section of Medical Pathology Mayo Clinic and Foundation Rochester, Minnesota 55905, USA

Correspondence to: 1 To whom correspondence should be addressed.

The lipid composition of nerves, with and without xanthomatous alteration, and other tissues, was investigated post-mortem in a 36-year-old man with cholestatic hepatitis of unknown cause and insulin-dependent diabetes mellitus (IDDM). Cholesteryl esters were found to be markedly increased in both endoneurium and epi- and perineurium of hepatic nerves (showing xanthomatous change), but not in sciatic nerve (without this change). Cholesteryl ester concentrations were also increased, but to a lesser degree, in kidney tissue. The fatty acid composition of stored cholesteryl esters in hepatic nerve endoneurium revealed that oleic acid was the most favoured substrate for esterification. A widespread depletion of triacylglycerol was also demonstrated in hepatic and sciatic nerves and liver and skin tissues obtained from this patient. This abnormality did not appear to be due to an alcoholic or biliary cirrhosis, or to inanition. Whether the depletion of triacylglycerol is drug-related or represents an endogenous metabolic error remains unclear.

Received September 6, 1983.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.