Brain, Vol. 107, No. 2, 619-636, 1984
© 1984 Oxford University Press
research-article |
EXPERIMENTAL GAZE PALSIES IN MONKEYS AND THEIR RELATION TO UMAN PATHOLOGY
The Departments of Neurology and Pathology, University Hospital, and the Department of Physics, Swiss Federal Institute of Technology Zürich, Switzerland
Correspondence to:
Correspondence to: Dr V. Henn, Department of Neurology, University Hospital, 8901 Zürich, Switzerland.
Lesions were placed in the paramedian pontine reticular formation (PPRF) of monkeys and the resulting gaze palsies studied. Brainstem regions were identified by single cell recordings before kainic acid was injected to selectively destroy neuronal cell bodies in the vicinity
Unilateral PPRF lesions led to a loss of all rapid eye movements towards the ipsilateral side. Deficits were identical to those after experimental electrolytic lesions in monkeys, or structural lesions in humans.
Bilateral PPRF lesions produced two different syndromes. Rostral PPRF lesions led to a selective loss of horizontal rapid eye movements leaving vertical movements intact. Caudal PPRF lesions led in addition to a severe disruption of vertical rapid eye movements.
Received June 28, 1983.
Revised October 20, 1983.
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