Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (85)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by TAYLOR, A. E.
Right arrow Articles by LANG, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TAYLOR, A. E.
Right arrow Articles by LANG, A. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 110, No. 1, 35-51, 1987
© 1987 Oxford University Press

research-article

PARKINSON'S DISEASE

COGNITIVE CHANGES IN RELATION TO TREATMENT RESPONSE

ANNE E. TAYLOR1,4,6, J. A. SAINT-CYR1,2,3,4,6, and A. E. LANG1,5,7

1From the Playfair Neuroscience Unit, University of Toronto 2From the Department of Anatomy, University of Toronto 3From the Department of Psychology, University of Toronto 4From the Institute of Medical Science, University of Toronto 5From the Department of Medicine, University of Toronto 6From the Department of Psychology, University of Toronto 7From the Department of Medicine, Division of Neurology, Toronto Western Hospital

Correspondence to: Correspondence to: Dr J. A. Saint-Cyr, Playfair Neuroscience Unit, Toronto Western Hospital, 399 Bathurst Street, Toronto, Canada M5T 2S8.

Four groups of patients with Parkinson's disease matched for age, education and IQ were categorized by response to treatment and compared with a normal control group. The patient groups were (1) No Treatment (de novo); (2) Good Response (including minor fluctuations in symptoms); (3) Fluctuations (significant, including ‘on-off’ phenomena) and/or marked Abnormal Involuntary Movements (dyskinesias); and (4) Poor Response (‘secondary treatment failure’ characterized by significant deterioration over time in all major symptoms). As a previous investigation had established that neuropsychological tests thought to be sensitive to the functional integrity of the frontal lobes are selectively impaired in Parkinson's disease, the first phase of this study compared the five groups on five such tests and two tests of psychomotor ability. While all patient groups displayed deficits on the psychomotor tests and on several tests associated with frontal lobe function compared with normals, only the Poor Response group was impaired on all tasks. In a second phase, comprehensive testing of additional cognitive processes such as attention, mnemonic, and visuospatial functions, the latter two traditionally thought to depend primarily on posterior cortical regions, revealed no significant cognitive deficits in any patient group. Results are discussed with respect to the involvement of the nigrostriatal and mesocortical dopaminergic systems.

Received December 3, 1985. Revised March 11, 1986. Accepted March 27, 1986.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
J. A. Saint-Cyr, L. L. Trepanier, R. Kumar, A. M. Lozano, and A. E. Lang
Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease
Brain, October 1, 2000; 123(10): 2091 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. K. York, H. S. Levin, R. G. Grossman, and W. J. Hamilton
Neuropsychological outcome following unilateral pallidotomy
Brain, December 1, 1999; 122(12): 2209 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
K. Perrine, M. Dogali, E. Fazzini, D. Sterio, E. Kolodny, D. Eidelberg, O. Devinsky, and A. Beric
Cognitive functioning after pallidotomy for refractory Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, August 1, 1998; 65(2): 150 - 154.
[Abstract] [Full Text]

Home page
 NeurologyHome page
L. L. Trepanier, J. A. Saint-Cyr, A. M. Lozano, and A. E. Lang
Neuropsychological consequences of posteroventral pallidotomy for the treatment of Parkinson's disease
Neurology, July 1, 1998; 51(1): 207 - 215.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
D. M. Roane, J. D. Rogers, J. H. Robinson, and T. E. Feinberg
Delusional Misidentification in Association With Parkinsonism
J Neuropsychiatry Clin Neurosci, May 1, 1998; 10(2): 194 - 198.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
H. C. Chui
Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships
Arch Neurol, July 1, 1989; 46(7): 806 - 814.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.