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Brain, Vol. 110, No. 1, 53-76, 1987
© 1987 Oxford University Press

research-article

CHRONIC DEMYELINATING PERIPHERAL NEUROPATHY ASSOCIATED WITH MULTIFOCAL CENTRAL NERVOUS SYSTEM DEMYELINATION

P. K. THOMAS, R. W. H. WALKER, P. RUDGE, J. A. MORGAN-HUGHES, R. H. M. KING, J. M. JACOBS, K. R. MILLS, I. E. C. ORMEROD, N. M. F MURRAY and W. I. MCDONALD

From the National Hospital for Nervous Diseases and Institute of Neurology Queen Square and The Royal Free Hospital School of Medicine London

Correspondence to: Correspondence to: Professor P. K. Thomas, Institute of Neurology, National Hospital, Queen Square, London WC1N3BG.

A series of 6 cases is described in which a chronic demyelinating neuropathy was associated with a relapsing multifocal CNS disorder, the clinical features of which resembled multiple sclerosis. Multifocal CNS lesions were demonstrated by CT and MR imaging and the presence of CNS demyelination was indicated by prolonged central conduction times. These cases are discussed in relation to the occurrence of combined peripheral and central demyelination in chronic relapsing experimental allergic encephalomyelitis and neuritis.

Received February 7, 1986. Accepted April 1, 1986.


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