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Brain, Vol. 110, No. 2, 517-532, 1987
© 1987 Oxford University Press

research-article

PHYSIOLOGICAL AND BEHAVIOURAL CONSEQUENCES OF SEIZURES INDUCED IN THE RAT BY INTRAHIPPOCAMPAL TETANUS TOXIN

JOHN G. R. JEFFERYS and SARAH F. WILLIAMS

Sobell Department of Neurophysiology, Institute of Neurology Queen Square, London

Correspondence to: Correspondence to: Dr. J.G.R. Jefferys, Department of Physiology and Biophysics, St Mary's Hospital Medical School, Norfolk Place, London W2 1PG.

Injecting tetanus toxin into rat hippocampus induces a syndrome of intermittent generalized seizures which recurs for about one month. Following remission from their seizures, the rats exhibit very persistent impairments of learning and memory. Learning was imparied on a circular platform task and a spatial reference memory task, and evoked responses from the commissural-CA3 pyramidal cell system were depressed for up to 22 weeks after injection. There was no significant loss of pyramidal neurons because antidromic responses, evoked from other parts of the commissural fibre system, were not affected by the toxin treatment. The depression of these pyramidal neurons provides a reasonable physiological explanation for the learning impairment. These results suggest that impairments of neuronal function can be significant factors in the development of interictal behavioural abnormalities.

Received December 17, 1985. Revised May 6, 1986. Accepted May 20, 1986.


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