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Brain, Vol. 110, No. 3, 683-694, 1987
© 1987 Guarantors of Brain

research-article

A MORPHOMETRIC STUDY ON SURAL NERVES IN METACHROMATIC LEUCODYSTROPHY

ATTILA BARDOSI1,, REINHARD L. FRIEDE1, SABINE ROPTE1 and HANS HILMAR GOEBEL2

1Department of Neuropathology, University of Göottingen D-3400 Gottingen 2Department of Neuropathology, University of Mainz Mainz, FRG

Correspondence to: Correspondence to: Dr Attila Bardosi, Abteilung Neuropathologie, Universitäat Göottingen, Robert-K.och-Strasse 40, D-3400 Göottingen, FRG.

This study reexamines peripheral neuropathy in infantile, juvenile and adult metachromatic leuco-dystrophy. A computer-assisted method was used which gives more detailed information on abnormal fibre structure from scatter diagrams of the g ratio (axon diameter/fibre diameter). The data show marked and statistically significant reductions in sheath thickness, particularly for the thick myelinated fibres, and most severe in the juvenile and adult forms. This is interpreted as evidence of remodelling of virtually the entire fibre population, without a clear-cut selectivity for either thin or thick fibres.

Received April 15, 1986. Revised July 25, 1986. Accepted August 5, 1986.


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