Brain, Vol. 110, No. 4, 1045-1059, 1987
© 1987 Guarantors of Brain
research-article |
COMPARISON OF CORTICAL AND SUBCORTICAL LESIONS IN THE PRODUCTION OF POSTSTROKE MOOD DISORDERS
1Departments of Psychiatry, The Johns Hopkins University School of Medicine Baltimore 2Departments of Neuroscience, The Johns Hopkins University School of Medicine Baltimore 3Department of Neurology, University of Maryland Medical School Baltimore, USA
Correspondence to:
Correspondence to: Dr Sergio E. Starkstein, Johns Hopkins University School of Medicine, Meyer 4–119, Department of Psychiatry, 600 North Wolfe Street, Baltimore, MD 21205, USA.
Patients with single stroke lesions, verified by computerized tomography, involving either cortical tissue or restricted entirely to subcortical structures were examined for mood disorders. Those with left anterior lesions, either cortical or subcortical, had significantly greater frequency and severity of depression than patients with any other lesion location. A strong correlation between the severity of depression and proximity of the lesion to the frontal pole was observed for both left cortical and subcortical groups. Right hemisphere lesions did not show the same correlation with depression but were associated with a significantly higher incidence of undue cheerfulness.
These findings demonstrate the importance of the location of subcortical lesions in poststroke mood disorders and suggest that anterior subcortical structures may play an important but lateralized role in the production or regulation of mood.
Received August 12, 1986. Revised November 11, 1986. Accepted November 14, 1986.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. G. Robinson, R. E. Jorge, and S. Arndt Escitalopram, Problem-Solving Therapy, and Poststroke Depression--Reply JAMA, October 15, 2008; 300(15): 1758 - 1759. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Paradiso, J. Vaidya, D. Tranel, T. Kosier, and R. G. Robinson Nondysphoric Depression Following Stroke J Neuropsychiatry Clin Neurosci, February 1, 2008; 20(1): 52 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Fiedorowicz, K. Takezawa, and R. G. Robinson Risk Factors for and Correlates of Poststroke Depression Following Discontinuation of Antidepressants J Neuropsychiatry Clin Neurosci, November 1, 2007; 19(4): 399 - 405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Townend, M. Brady, and K. McLaughlan A Systematic Evaluation of the Adaptation of Depression Diagnostic Methods for Stroke Survivors Who Have Aphasia Stroke, November 1, 2007; 38(11): 3076 - 3083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Medina and S. Weintraub Depression in Primary Progressive Aphasia J Geriatr Psychiatry Neurol, September 1, 2007; 20(3): 153 - 160. [Abstract] [PDF]
|
|
|
|
|
|
W. K. Tang, S. S. M. Chan, H. F. K. Chiu, G. S. Ungvari, K. S. Wong, T. C. Y. Kwok, V. Mok, K. T. Wong, P. S. Richards, and A. T. Ahuja Poststroke Depression in Chinese Patients: Frequency, Psychosocial, Clinical, and Radiological Determinants J Geriatr Psychiatry Neurol, March 1, 2005; 18(1): 45 - 51. [Abstract] [PDF]
|
|
|
|
|
|
R. Vataja, A. Leppavuori, T. Pohjasvaara, R. Mantyla, H. J. Aronen, O. Salonen, M. Kaste, and T. Erkinjuntti Poststroke Depression and Lesion Location Revisited J Neuropsychiatry Clin Neurosci, May 1, 2004; 16(2): 156 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Verdelho, H. Henon, F. Lebert, F. Pasquier, and D. Leys Depressive symptoms after stroke and relationship with dementia: A three-year follow-up study Neurology, March 23, 2004; 62(6): 905 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bhogal, R. Teasell, N. Foley, and M. Speechley Lesion Location and Poststroke Depression: Systematic Review of the Methodological Limitations in the Literature Stroke, March 1, 2004; 35(3): 794 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Narushima, J. T. Kosier, and R. G. Robinson A Reappraisal of Poststroke Depression, Intra- and Inter-Hemispheric Lesion Location Using Meta-Analysis J Neuropsychiatry Clin Neurosci, November 1, 2003; 15(4): 422 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huffman and T. A. Stern Acute Psychiatric Manifestations of Stroke: A Clinical Case Conference Psychosomatics, February 1, 2003; 44(1): 65 - 75. [Full Text] [PDF]
|
|
|
|
|
|
A. Tateno, Y. Murata, and R. G. Robinson Comparison of Cognitive Impairment Associated With Major Depression Following Stroke Versus Traumatic Brain Injury Psychosomatics, August 1, 2002; 43(4): 295 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.P. Crucian, L. Huang, A.M. Barrett, R.L. Schwartz, J.E. Cibula, J. M. Anderson, W.J. Triggs, D. Bowers, W.A. Friedman, M. Greer, et al. Emotional conversations in Parkinson's disease Neurology, January 23, 2001; 56(2): 159 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Morrow, C. Gibson, G. R. Bagovich, L. Stein, R. Condray, and A. Scott Increased Incidence of Anxiety and Depressive Disorders in Persons With Organic Solvent Exposure Psychosom Med, December 1, 2000; 62(6): 746 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Robinson An 82-Year-Old Woman With Mood Changes Following a Stroke JAMA, March 22, 2000; 283(12): 1607 - 1614. [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, S. E. Black, N. Herrmann, F. S. Leibovitch, P. L. Ebert, J. Lawrence, and J. P. Szalai Functional and Neuroanatomic Correlations in Poststroke Depression : The Sunnybrook Stroke Study Stroke, March 1, 2000; 31(3): 637 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Barak, Y. Lampl, Ehud. Bodner, and I. S. Pinchas Perception of Body Esteem Following Stroke Neurorehabil Neural Repair, March 1, 1999; 13(1): 1 - 4. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Nass, J. Melnick, and A. Berenstein Temperament Profiles of Children With Vein of Galen Malformations J Child Neurol, August 1, 1998; 13(8): 387 - 390. [Abstract] [PDF]
|
|
|
|
 |
|
 L M Sutcliffe and N B Lincoln The assessment of depression in aphasic stroke patients: the development of the Stroke Aphasic Depression Questionnaire Clinical Rehabilitation, June 1, 1998; 12(6): 506 - 513. [Abstract] [PDF]
|
|
|
|
 |
|
 S. M MacHale, S. J O'Rourke, J. M Wardlaw, and M. S Dennis Depression and its relation to lesion location after stroke J. Neurol. Neurosurg. Psychiatry, March 1, 1998; 64(3): 371 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paradiso and R. G. Robinson Gender Differences in Poststroke Depression J Neuropsychiatry Clin Neurosci, February 1, 1998; 10(1): 41 - 47. [Abstract] [Full Text]
|
|
|
|
|
|
C. G. Lyketsos, G. J. Treisman, J. R. Lipsey, P. L.P. Morris, and R. G. Robinson Does Stroke Cause Depression? J Neuropsychiatry Clin Neurosci, February 1, 1998; 10(1): 103 - 107. [Full Text]
|
|
|
|
 |
|
 R. M. Lane SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment J Psychopharmacol, January 1, 1998; 12(2): 192 - 214. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Amsterdam Selective serotonin reuptake inhibitor efficacy in severe and melancholic depression J Psychopharmacol, January 1, 1998; 12(4_suppl): S99 - S111. [Abstract] [PDF]
|
|
|
|
|
|
S. Kumar, R. R Jacobson, and K Sathananthan Seasonal cyclothymia to seasonal bipolar affective disorder: a double switch after stroke J. Neurol. Neurosurg. Psychiatry, December 1, 1997; 63(6): 796 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gainotti, A. Azzoni, F. Gasparini, C. Marra, and C. Razzano Relation of Lesion Location to Verbal and Nonverbal Mood Measures in Stroke Patients Stroke, November 1, 1997; 28(11): 2145 - 2149. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Paydarfar and S. M. de la Monte Case 12-1997- A 50-Year-Old Woman with Multiple Sclerosis and an Enlarging Frontal-Lobe Mass N. Engl. J. Med., April 17, 1997; 336(16): 1163 - 1171. [Full Text] [PDF]
|
|
|
|
|
|
M. Herrmann, C. Bartels, M. Schumacher, and C.-W. Wallesch Poststroke Depression : Is There a Pathoanatomic Correlate for Depression in the Postacute Stage of Stroke? Stroke, May 1, 1995; 26(5): 850 - 856. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. I. Victoroff, D. F. Benson, S. T. Grafton, J. Engel Jr, and J. C. Mazziotta Depression in Complex Partial Seizures Electroencephalography and Cerebral Metabolic Correlates Arch Neurol, February 1, 1994; 51(2): 155 - 163. [Abstract] [PDF]
|
|
|
|
|
|
E. Irle, M. Peper, B. Wowra, and S. Kunze Mood Changes After Surgery for Tumors of the Cerebral Cortex Arch Neurol, February 1, 1994; 51(2): 164 - 174. [Abstract] [PDF]
|
|
|
|
|
|
J. L. Cummings Frontal-Subcortical Circuits and Human Behavior Arch Neurol, August 1, 1993; 50(8): 873 - 880. [Abstract] [PDF]
|
|
|
|
|
|
K. R. R. Krishnan Neuroanatomic Substrates of Depression in the Elderly J Geriatr Psychiatry Neurol, January 1, 1993; 6(1): 39 - 58. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Kobayashi, S. Yamaguchi, K. Okada, N. Suyama, K. Bokura, M. Murao, and T. Tsunematsu Effect of Single Oral Administration of Nilvadipine on Cerebral Blood Flow in Chronic Cerebral Infarction Angiology, October 1, 1992; 43(10): 801 - 809. [Abstract] [PDF]
|
|
|
|
 |
|
 K. R. R. Krishnan, W. M. McDonald, P. R. Escalona, P. M. Doraiswamy, C. Na, M. M. Husain, G. S. Figiel, O. B. Boyko, E. H. Ellinwood, and C. B. Nemeroff Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations Arch Gen Psychiatry, July 1, 1992; 49(7): 553 - 557. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Figiel, K. R. R. Krishnan, P. M. Doraiswamy, and C. B. Nemeroff Caudate Hyperintensities in Elderly Depressed Patients With Neuroleptic-Induced Parkinsonism J Geriatr Psychiatry Neurol, April 1, 1991; 4(2): 86 - 89. [Abstract] [PDF]
|
|
|
|
|
|
R. M. Parikh, R. G. Robinson, J. R. Lipsey, S. E. Starkstein, J. P. Fedoroff, and T. R. Price The Impact of Poststroke Depression on Recovery in Activities of Daily Living Over a 2-Year Follow-up Arch Neurol, July 1, 1990; 47(7): 785 - 789. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Starkstein, B. S. Cohen, P. Fedoroff, R. M. Parikh, T. R. Price, and R. G. Robinson Relationship Between Anxiety Disorders and Depressive Disorders in Patients With Cerebrovascular Injury Arch Gen Psychiatry, March 1, 1990; 47(3): 246 - 251. [Abstract] [PDF]
|
|
|
|
|
|
L. R. Caplan, J. D. Schmahmann, C. S. Kase, E. Feldmann, G. Baquis, J. P. Greenberg, P. B. Gorelick, C. Helgason, and D. B. Hier Caudate Infarcts Arch Neurol, February 1, 1990; 47(2): 133 - 143. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Starkstein, R. G. Robinson, M. L. Berthier, R. M. Parikh, and T. R. Price Differential Mood Changes Following Basal Ganglia vs Thalamic Lesions Arch Neurol, July 1, 1988; 45(7): 725 - 730. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Starkstein, R. G. Robinson, and T. R. Price Comparison of Patients With and Without Poststroke Major Depression Matched for Size and Location of Lesion Arch Gen Psychiatry, March 1, 1988; 45(3): 247 - 252. [Abstract] [PDF]
|
|