Brain, Vol. 110, No. 6, 1617-1630, 1987
© 1987 Guarantors of Brain
research-article |
CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY
A CLINICAL AND ELECTROPHYSIOLOGICAL STUDY OF 92 CASES
Department of Medicine, University of Sydney Australia
Correspondence to:
Professor J. G. McLeod, Department of Medicine, University of Sydney NSW 2006, Australia
Ninety-two patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been studied in order to define better the clinical features, course and prognosis of the condition and to identify possible aetiological factors. Sural nerve biopsy was performed on 87 subjects. Electrophysiological studies were undertaken on all patients and demonstrated marked slowing of motor conduction and impairment of sensory conduction. The onset was usually gradual but there was a rapid rate of onset in 15 (16%) patients. Males were more commonly affected than females. Weakness and paraesthesiae were the most common symptoms but pain was frequently a feature. Age of onset ranged from 2 to 72 years. Sixty patients (65%) had a relapsing course and 32 patients (35%) a progressive or monophasic course; there was a significantly earlier age of onset in patients with relapsing disease. Thirty-two patients (35%) gave a history of preceding infection or some other possible antecedent precipitating event and there was a significantly higher titre for cytomegalovirus antibodies in the serum of patients with CIDP than in controls. The patients were followed up for an average time of approximately ten years. Most patients (73%) had made a good recovery and were independent, but 7 patients had either died or were completely immobilized as a result of their disease. The value of treatment with corticosteroid therapy, immunosuppressive agents and plasma exchange is discussed.
Received December 9, 1986. Revised March 12, 1987. Accepted March 23, 1987.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M P T Lunn and H J Willison Diagnosis and treatment in inflammatory neuropathies Postgrad. Med. J., August 1, 2009; 85(1006): 437 - 446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M P T Lunn and H J Willison Diagnosis and treatment in inflammatory neuropathies J. Neurol. Neurosurg. Psychiatry, March 1, 2009; 80(3): 249 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Kuitwaard, R van Koningsveld, L Ruts, B C Jacobs, and P A van Doorn Recurrent Guillain-Barre syndrome J. Neurol. Neurosurg. Psychiatry, January 1, 2009; 80(1): 56 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Muley, P. Kelkar, and G. J. Parry Treatment of Chronic Inflammatory Demyelinating Polyneuropathy With Pulsed Oral Steroids Arch Neurol, November 1, 2008; 65(11): 1460 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The French CIDP Study Group Recommendations on diagnostic strategies for chronic inflammatory demyelinating polyradiculoneuropathy Postgrad. Med. J., July 1, 2008; 84(993): 378 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The French CIDP Study Group Recommendations on diagnostic strategies for chronic inflammatory demyelinating polyradiculoneuropathy J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 115 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Chio, D Cocito, E Bottacchi, C Buffa, M Leone, F Plano, R Mutani, A Calvo, and the PARCIDP Idiopathic chronic inflammatory demyelinating polyneuropathy: an epidemiological study in Italy J. Neurol. Neurosurg. Psychiatry, December 1, 2007; 78(12): 1349 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Oyama, R. Sufit, Y. Loh, L. Statkute, K. Yaung, K. Quigley, E. Gonda, D. Spahovic, D. Bronesky, and R. K. Burt NONMYELOABLATIVE AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR REFRACTORY CIDP Neurology, October 30, 2007; 69(18): 1802 - 1803. [Full Text] [PDF]
|
|
|
|
|
|
H R Inglis, P A Csurhes, and P A McCombe Antibody responses to peptides of peripheral nerve myelin proteins P0 and P2 in patients with inflammatory demyelinating neuropathy J. Neurol. Neurosurg. Psychiatry, April 1, 2007; 78(4): 419 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Kuwabara, S Misawa, M Mori, N Tamura, M Kubota, and T Hattori Long term prognosis of chronic inflammatory demyelinating polyneuropathy: a five year follow up of 38 cases J. Neurol. Neurosurg. Psychiatry, January 1, 2006; 77(1): 66 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ruts, R. van Koningsveld, and P. A. van Doorn Distinguishing acute-onset CIDP from Guillain-Barre syndrome with treatment related fluctuations Neurology, July 12, 2005; 65(1): 138 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lopate, A. Pestronk, and M. Al-Lozi Treatment of Chronic Inflammatory Demyelinating Polyneuropathy With High-Dose Intermittent Intravenous Methylprednisolone Arch Neurol, February 1, 2005; 62(2): 249 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. V. Toyka and R. Gold The pathogenesis of CIDP: Rationale for treatment with immunomodulatory agents Neurology, April 22, 2003; 60(90083): S2 - 7. [Abstract] [Full Text]
|
|
|
|
|
|
A. H. Ropper Current treatments for CIDP Neurology, April 22, 2003; 60(90083): S16 - 22. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. W. Sander and E. T. Hedley-Whyte Case 6-2003 - A Nine-Year-Old Girl with Progressive Weakness and Areflexia N. Engl. J. Med., February 20, 2003; 348(8): 735 - 743. [Full Text] [PDF]
|
|
|
|
|
|
B. C. Kieseier, M. C. Dalakas, and H.-P. Hartung Immune mechanisms in chronic inflammatory demyelinating neuropathy Neurology, December 24, 2002; 59(90126): S7 - 12. [Abstract] [Full Text]
|
|
|
|
|
|
K. Mori, N. Hattori, M. Sugiura, H. Koike, K. Misu, M. Ichimura, M. Hirayama, and G. Sobue Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS Neurology, March 26, 2002; 58(6): 979 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Kuwabara, K Ogawara, S Misawa, M Mori, and T Hattori Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy J. Neurol. Neurosurg. Psychiatry, January 1, 2002; 72(1): 37 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Vermeulen and M H Van Oers Successful autologous stem cell transplantation in a patient with chronic inflammatory demyelinating polyneuropathy J. Neurol. Neurosurg. Psychiatry, January 1, 2002; 72(1): 127 - 128. [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. J. Bosboom, L. H. van den Berg, H. Franssen, P. C. L. M. Giesbergen, H. Z. Flach, A. M. van Putten, H. Veldman, and J. H. J. Wokke Diagnostic value of sural nerve demyelination in chronic inflammatory demyelinating polyneuropathy Brain, December 1, 2001; 124(12): 2427 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Misawa, S. Kuwabara, M. Mori, N. Kawaguchi, Y. Yoshiyama, and T. Hattori Serum levels of tumor necrosis factor-{{alpha}} in chronic inflammatory demyelinating polyneuropathy Neurology, March 13, 2001; 56(5): 666 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.R. Mendell, R.J. Barohn, M.L. Freimer, J.T. Kissel, W. King, H.N. Nagaraja, R. Rice, W.W. Campbell, P.D. Donofrio, C.E. Jackson, et al. Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy Neurology, February 27, 2001; 56(4): 445 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.M.J. Bosboom, L.H. Van den Berg, I. Mollee;, L.D. Sasker;, J. Jansen, J.H.J. Wokke, and T. Logtenberg Sural nerve T-cell receptor V{beta} gene utilization in chronic inflammatory demyelinating polyneuropathy and vasculitic neuropathy Neurology, January 9, 2001; 56(1): 74 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. U. Haq, T. J. Fries, W. W. Pendlebury, M. J. Kenny, G. J. Badger, and R. Tandan Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Study of Proposed Electrodiagnostic and Histologic Criteria Arch Neurol, December 1, 2000; 57(12): 1745 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hara, K. Minami, K. Takamoto, M. Shiraishi, and T. Sata The Prolonged Effect of a Muscle Relaxant in a Patient with Chronic Inflammatory Demyelinating Polyradiculoneuropathy Anesth. Analg., January 1, 2000; 90(1): 224 - 224. [Full Text] [PDF]
|
|
|
|
|
|
J Duarte, A C. Martinez, F Rodriguez, A Mendoza, A P Sempere, and L E Claveria Hypertrophy of multiple cranial nerves and spinal roots in chronic inflammatory demyelinating neuropathy J. Neurol. Neurosurg. Psychiatry, November 1, 1999; 67(5): 685 - 687. [Full Text]
|
|
|
|
 |
|
 E. F. de Maar, D. M. Kas-Deelen, A. E. J. de Jager, H. The, A. M. Tegzess, and W. J. van Son Inflammatory demyelinating polyneuropathy in a kidney transplant patient with cytomegalovirus infection Nephrol. Dial. Transplant., September 1, 1999; 14(9): 2228 - 2230. [Full Text] [PDF]
|
|
|
|
|
|
W. M. J. Bosboom, L. H. Van den Berg, L. De Boer, M. J. Van Son, H. Veldman, H. Franssen, T. Logtenberg, and J. H. J. Wokke The diagnostic value of sural nerve T cells in chronic inflammatory demyelinating polyneuropathy Neurology, September 1, 1999; 53(4): 837 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. M. Hadden, B. Sharrack, S. Bensa, S. E. Soudain, and R. A. C. Hughes Randomized trial of interferon {beta}-1a in chronic inflammatory demyelinating polyradiculoneuropathy Neurology, July 1, 1999; 53(1): 57 - 57. [Abstract] [Full Text]
|
|
|
|
|
|
M P T Lunn, H Manji, P P Choudhary, R A C Hughes, and P K Thomas Chronic inflammatory demyelinating polyradiculoneuropathy: a prevalence study in south east England J. Neurol. Neurosurg. Psychiatry, May 1, 1999; 66(5): 677 - 680. [Abstract] [Full Text]
|
|
|
|
|
|
C. Bouchard, C. Lacroix, V. Plante, D. Adams, F. Chedru, J.-M. Guglielmi, and G. Said Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy Neurology, February 1, 1999; 52(3): 498 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. North NEW PERSPECTIVES IN PEDIATRIC NEUROMUSCULAR DISORDERS Hotel Intercontinental Sydney, Sydney, Australia, August 28, 1998 J Child Neurol, January 1, 1999; 14(1): 26 - 57. [PDF]
|
|
|
|
|
|
D S M Molenaar, M Vermeulen, and R de Haan Diagnostic value of sural nerve biopsy in chronic inflammatory demyelinating polyneuropathy J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 84 - 89. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Comi, R. Nemni, S. Amadio, G. Galardi, and L. Leocani Intravenous immunoglobulin treatment in multifocal motor neuropathy and other chronic immune-mediated neuropathies Multiple Sclerosis, April 1, 1997; 3(2): 93 - 97. [Abstract] [PDF]
|
|
|
|
|
|
D. Weinberg and E. J. Mark Case 32-1994- A 61-Year-Old Man with Muscular Weakness N. Engl. J. Med., August 25, 1994; 331(8): 528 - 535. [Full Text]
|
|
|
|
|
|
R. Hughes, E. Sanders, S. Hall, P. Atkinson, A. Colchester, and P. Payan Subacute Idiopathic Demyelinating Polyradiculoneuropathy Arch Neurol, June 1, 1992; 49(6): 612 - 616. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Shefner and D. M. Dawson The Use of Sensory Action Potentials in the Diagnosis of Peripheral Nerve Disease Arch Neurol, March 1, 1990; 47(3): 341 - 348. [Abstract] [PDF]
|
|
|
|
|
|
E. F. M. Wijdicks and A. H. Ropper Acute Relapsing Guillain-Barre Syndrome After Long Asymptomatic Intervals Arch Neurol, January 1, 1990; 47(1): 82 - 84. [Abstract] [PDF]
|
|
|
|
|
|
R. J. Barohn, J. T. Kissel, J. R. Warmolts, and J. R. Mendell Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Clinical Characteristics, Course, and Recommendations for Diagnostic Criteria Arch Neurol, August 1, 1989; 46(8): 878 - 884. [Abstract] [PDF]
|
|