Brain, Vol. 110, No. 6, 1675-1698, 1987
© 1987 Guarantors of Brain
research-article |
VISUAL DYSFUNCTION IN PARKINSON'S DISEASE
LOSS IN SPATIOTEMPORAL CONTRAST SENSITIVITY
1From the VEP Laboratory, Departments of Neurology, Mount Sinai School of Medicine of the City University of New York USA 2Departments of Ophthalmology, Mount Sinai School of Medicine of the City University of New York USA
Correspondence to:
Dr I. Bodis-Wollner, Box 1052, The Mount Sinai Medical Center, I Gustave Levy Place, New York, NY 10029, USA.
Flicker sensitivity and spatial contrast sensitivity (CS) were examined in a total of 99 patients with Parkinson's disease (PD). All patients were undergoing treatment with dopaminergic agents. Specific losses in sensitivity observed in PD were (1) a loss in flicker sensitivity which was most pronounced around the peak of the function (8 Hz) and (2) a loss near the peak of the spatial CS curve, often with no noticeable low frequency attenuation. Several PD patients affected by the ‘on-off ’ syndrome were tested in both ‘on’ and ‘off’ phases, and the results show that the CS function switches in parallel with motor symptoms of the disease. These data suggest that not only is the visual system affected in PD, but that dopamine may have an essential role in receptive field organization in human vision.
Received January 30, 1986. Revised January 5, 1987. Accepted April 16, 1987.
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