Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (70)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by RIDLEY, A.
Right arrow Articles by TURNBULL, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by RIDLEY, A.
Right arrow Articles by TURNBULL, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 110, No. 6, 1699-1709, 1987
© 1987 Guarantors of Brain

research-article

OMNIPAUSE NEURONS IN TWO CASES OF OPSOCLONUS ASSOCIATED WITH OAT CELL CARCINOMA OF THE LUNG

A. RIDLEY1, C. KENNARD1,, C.L. SCHOLTZ1, J.A. B{diaeresis}TTNER-ENNEVER3, B. SUMMERS1 and A. TURNBULL2

1From the Sections of Neurological Science, The London Hospital London, UK 2Sections of Department of Haematology, The London Hospital London, UK 3Institute of Neuropathology, University of Munich West Germany

Correspondence to: Dr C. Kennard, Department of Neurology, The London Hospital, Whitechapel, London El IBB.

Opsoclonus is an involuntary eye movement disorder in which there are chaotic, usually conjugate, multidimensional saccadic eye movements. In this paper 2 cases of opsoclonus are reported, as a paraneoplastic phenomenon in association with oat cell carcinoma of the lung. It has previously been hypothesized that opsoclonus results from dysfunction of a group of premotor neurons in the brainstem called omnipause neurons. We describe the location of these cells in man by homology with animal studies, and describe the light microscopic appearance of these neurons in the 2 cases of opsoclonus. Although these neurons appeared normal it is still possible that their function was disturbed as a result of metabolic or neurotransmitter abnormalities.

Received January 29, 1987. Revised April 7, 1987. Accepted April 21, 1987.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
S. Ramat, R. J. Leigh, D. S. Zee, and L. M. Optican
What clinical disorders tell us about the neural control of saccadic eye movements
Brain, January 1, 2007; 130(1): 10 - 35.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. S. Espinosa and J. R. Berger
Volitional opsoclonus
Neurology, September 13, 2005; 65(5): E11 - E11.
[Full Text] [PDF]

Home page
 BrainHome page
R. J. Leigh and C. Kennard
Using saccades as a research tool in the clinical neurosciences
Brain, March 1, 2004; 127(3): 460 - 477.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. B. Darnell and J. B. Posner
Paraneoplastic Syndromes Involving the Nervous System
N. Engl. J. Med., October 16, 2003; 349(16): 1543 - 1554.
[Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M C VIGLIANI, L PALMUCCI, P POLO, R MUTANI, D SCHIFFER, S DE LUCA, and A DE ZAN
Paraneoplastic opsoclonus-myoclonus associated with renal cell carcinoma and responsive to tumour ablation
J. Neurol. Neurosurg. Psychiatry, June 1, 2001; 70(6): 814 - 815.
[Full Text]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A. AGGARWAL and D. WILLIAMS
Opsoclonus as a paraneoplastic manifestation of pancreatic carcinoma
J. Neurol. Neurosurg. Psychiatry, November 1, 1997; 63(5): 687 - 688.
[Full Text]

Home page
 Arch NeurolHome page
P. Pullicino and J. Aquilina
Opsoclonus in Organophosphate Poisoning
Arch Neurol, June 1, 1989; 46(6): 704 - 705.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.