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Brain, Vol. 112, No. 3, 565-581, 1989
© 1989 Guarantors of Brain

research-article

THE ROLE OF CEREBELLAR STRUCTURES IN THE EXECUTION OF SERIAL MOVEMENTS

ALBRECHT WERNER INHOFF1,, HANS CHRISTOPH DIENER2, ROBERT D. RAFAL3 and RICHARD IVRY4

1Department of Psychology, State University of New York Binghamton 2Department of Neurology, Eberhard-Karls-Universität Tübingen, Germany 3Department of Clinical Neuroscience at Roger Williams General Hospital and Brown University Program in Medicine Providence, RI 4Neuropsychology Laboratory, Good Samaritan Hospital and Medical Center Portland, Oregon, USA

Correspondence to: Correspondence to Dr Albrecht Inhoff, Department of Psychology, SUNY-Binghamton, Binghamton, NY 13901, USA

SUMMARY

Thirteen patients with bilateral cerebellar disease and 12 patients with unilateral cerebellar disease were instructed to execute movement sequences in response to a simple reaction signal. Each to-be-executed sequence consisted either of a single, two, or three keypress components Evidence for cerebellar involvement in the execution of programmed responses was sought in the pattern of response onset times and interkeypress times Patients with mild bilateral cerebellar dysfunction or mild unilateral dysfunction, and neurologically unimpaired subjects showed increases in response onset time as sequence length increased from L = 1 to L = 3 In contrast to this, there were negligible or no effects of sequence length on response onset time in patients with moderate bilateral cerebellar dysfunction and in patients with moderate unilateral cerebellar dysfunction who responsed with the hand ipsilateral to the lesion. Furthermore, cerebellar dysfunction was associated with significantly slower interkeypress reaction times. These results support the hypothesis that the translation of a programmed sequence of responses into action involves cerebellar structures which schedule a sequence of ordered responses before onset of movement

Received July 21, 1987. Revised March 15, 1988. Accepted June 7, 1988.


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