Brain, Vol. 112, No. 5, 1141-1153, 1989
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research-article |
DEPRESSION AND COGNITIVE IMPAIRMENT IN PARKINSON'S DISEASE
1Departments of Psychiatry and Behavioral Sciences Baltimore, MD, USA 2Departments of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA 3Department of Neurology, British Hospital Buenos Aires 4Departments of Neurosciences Baltimore, MD, USA 5Institute of Neurological Research ‘Dr. Raul Carrea’ Buenos Aires, Argentina
Correspondence to:
Correspondence to Dr Sergio E. Starkstein, Meyer 4-119, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21205, USA
Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD) It has never been determined, however, whether there is a specific relationship between cognitive impairment and depression. A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested These impairments were most pronounced on frontal lobe tasks.
Received June 29, 1988. Revised November 1, 1988. Accepted November 5, 1988.
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