Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MIX, E.
Right arrow Articles by LINK, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MIX, E.
Right arrow Articles by LINK, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 112, No. 6, 1405-1418, 1989
© 1989 Guarantors of Brain

research-article

EFFECT OF ION CHANNEL BLOCKERS ON IMMUNE RESPONSE AND COURSE OF EXPERIMENTAL ALLERGIC NEURITIS

EILHARD MIX1,*, TOMAS OLSSON1,, GÖRAN SOLDERS1,2 and HANS LINK1

1Departments of Neurology Karolinska Institutet, Huddinge University Hospital Stockholm, Sweden 2Department of Clinical Neurophysiology, Karolinska Institutet, Huddinge University Hospital Stockholm, Sweden

Correspondence to: Correspondence to: Dr Tomas Olsson, Department of Neurology, Karolinska Institutet, Huddinge University Hospital, S-141 86 Huddinge, Sweden

The influence of the K+ channel blocker quinidine and the Ca++ channel blocker verapamil on in vivo and in vitro immune responses was tested in experimental allergic neuritis (EAN) of Lewis rats. Daily intraperitoneal injections of 4 mg quinidine produced a significant reduction of neurological deficits in EAN rats, whereas verapamil had no effect. In contrast, both drugs inhibited the in viteo proliferative response of regional lymph node cells to specific antigens of bovine peripheral myelin ad purified rpotein derivatie of tyberculin in a similar dose-dependent manner. Quinidine-treated EAN rats revealed considerably less inflammatory infiltration in target tissue than untreated EAN rats, shown immunohistochemically. Single injections of ion channel blockers into EAN rats did not improve nerve cell functions as measured by electrophysiological recordings of sciatic nerve. It is concluded that the dominant effect of quidinine in vivo is attributed to a reduction of the demyelinating autoimmune process. Hence ion channel blocking drugs can exert immunomodulatory effects, which may have implications for their clinical application.

.

Received July 18, 1988. Revised December 9, 1988. Accepted December 13, 1988.

*Guest scientist from the Clinic for Psychiatry and Neurology, Wilhelm-Pieck University, Rostock, GDR


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.