Brain, Vol. 112, No. 6, 1533-1548, 1989
© 1989 Guarantors of Brain
research-article |
THE ROLE OF THE SUBTHALAMIC NUCLEUS IN EXPERIMENTAL CHOREA
EVIDENCE FROM 2-DEOXYGLUCOSE METABOLIC MAPPING AND HORSERADISH PEROXIDASE TRACING STUDIES
Experimental Neurology Group, Department of Cell and Structural Biology, School of Biological Sciences, University of Manchester Manchester, UK
Correspondence to:
Correspondence to: Professor A. R Crossman, Department of Cell and Structural Biology, School of Biological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
In previous studies we have shown that hemichorea can be induced in the conscious monkey by localized injection of gamma-aminobutyric acid (GABA) antagonists into the contralateral lentiform complex. It has been argued that the primary site of drug action in inducing chorea is the lateral segment of the globus pallidus. In the present study, the neural mechanisms which underlie this experimental dyskinesia were investigated by two separate approaches. First, the efferent projections of the lentiform complex were mapped using neuroanatomical tracing techniques. This involved injecting horseradish peroxide into sites which had previously given chorea when injected with the GABA antagonist bicuculline. Secondly, the 2-deoxyglucose (2-DG) metabolic mapping technique was applied to animals during active dyskinesia. This procedure permitted the autoradiographic measurement of local cerebral glucose uptake which was used as an index of regional synaptic activity. In both instances, the strongest labelling was seen in the dorsolateral region of the subthalamic nucleus. On the basis of this finding it is suggested that the pallidosubthalamic pathway plays a crucial role in the mediation of experimentally-induced chorea. Specifically, the pallidosubthalamic pathway arising from the lateral pallidal segment is abnormally overactive, which causes physiological inhibition of the subthalamic nucleus. The pattern of 2-DG uptake in the medial segment of the globus pallidus and thalamus was similar to that seen in animals with experimentally-induced ballism. This similarity is interpreted as suggesting that a common neural mechanism underlies both experimentally-induced chorea and ballism.
Received November 1, 1988. Revised January 31, 1989. Accepted February 14, 1989.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. A. Ford and S. Everling Neural Activity in Primate Caudate Nucleus Associated With Pro- and Antisaccades J Neurophysiol, October 1, 2009; 102(4): 2334 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Lee, L. Verhagen Metman, S. Ohara, P. M. Dougherty, J. H. Kim, and F. A. Lenz Internal Pallidal Neuronal Activity During Mild Drug-Related Dyskinesias in Parkinson's Disease: Decreased Firing Rates and Altered Firing Patterns J Neurophysiol, April 1, 2007; 97(4): 2627 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A C Pereira and T. Z Aziz Surgical insights into Parkinson's disease. J R Soc Med, May 1, 2006; 99(5): 238 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E A C Pereira and T Z Aziz Parkinson's disease and primate research: past, present, and future. Postgrad. Med. J., May 1, 2006; 82(967): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lehericy, E. Bardinet, L. Tremblay, P.-F. Van de Moortele, J.-B. Pochon, D. Dormont, D.-S. Kim, J. Yelnik, and K. Ugurbil Motor control in basal ganglia circuits using fMRI and brain atlas approaches Cereb Cortex, February 1, 2006; 16(2): 149 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lehericy, H. Benali, P.-F. Van de Moortele, M. Pelegrini-Issac, T. Waechter, K. Ugurbil, and J. Doyon Distinct basal ganglia territories are engaged in early and advanced motor sequence learning PNAS, August 30, 2005; 102(35): 12566 - 12571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Guridi and J. A. Obeso The subthalamic nucleus, hemiballismus and Parkinson's disease: reappraisal of a neurosurgical dogma Brain, January 1, 2001; 124(1): 5 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J A OBESO, G LINAZASORO, J GURIDI, E RAMOS, J A OBESO, M C RODRIGUEZ-OROZ, J GURIDI, R. FIGUEIRAS-MÉNDEZ, F. MARÍN-ZARZA, J. A. MOLINA, et al. High frequency stimulation of the subthalamic nucleus and levodopa induced dyskinesias in Parkinson's disease J. Neurol. Neurosurg. Psychiatry, January 1, 2000; 68(1): 122 - 123. [Full Text]
|
|
|
|
 |
|
 P. H. Lee, H. S. Nam, K. Y. Lee, B. I. Lee, and J. D. Lee Serial Brain SPECT Images in a Case of Sydenham Chorea Arch Neurol, February 1, 1999; 56(2): 237 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Lancman, J. J. Asconape, and J. K. Penry Choreiform Movements Associated With the Use of Valproate Arch Neurol, July 1, 1994; 51(7): 702 - 704. [Abstract] [PDF]
|
|
|
|
 |
|
 I.J. Mitchell Mso Prize for Young Pharmacologist: Striatal outputs and dyskinesia J Psychopharmacol, January 1, 1990; 4(4): 188 - 197. [PDF]
|
|