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Brain, Vol. 113, No. 1, 121-137, 1990
© 1990 Oxford University Press

research-article

REEVALUATION OF THE ULTRASTRUCTURAL PATHOLOGY OF EXPERIMENTAL CREUTZFELDT-JAKOB DISEASE

SERIAL STUDIES OF THE FUJISAKI STRAIN OF CREUTZFELDT-JAKOB DISEASE VIRUS IN MICE

PAWEL P. LIBERSKI, RICHARD YANAGIHARA, DAVID M. ASHER, CLARENCE J. GIBBS, JR and D. CARLETON GAJDUSEK

Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda, Maryland, USA

Correspondence to: Correspondence to: Dr R. Yanagihara, Building 36, Room 5B-21, National Institutes of Health, Bethesda, MD 20892, USA

We describe the serial ultrastructural pathology of experimental Creutzfeldt-Jakob disease (CJD) in mice. Spongiform vacuoles, widespread myelin and axonal pathology, accompanied by abundant macrophagic reaction and neuroaxonal dystrophy. Were consistently found in mice infected with CJD virus. By contrast, intranuclear vacuolation and swelling of astrocytic and neuronal processes were nonspecific changes that also occurred in control animals. We conclude that CJD-related neuropathological phenomena do not accumulate gradually through the incubation period but develop relatively abruptly and in complete form.

Received December 9, 1988. Revised March 31, 1989. Accepted April 19, 1989.


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