Brain, Vol. 113, No. 1, 85-101, 1990
© 1990 Oxford University Press
research-article |
THREE-DIMENSIONAL COMPUTERGRAPHIC ANALYSIS OF APRAXIA
NEURAL REPRESENTATIONS OF LEARNED MOVEMENT
The Salk Institute for Biological Studies, the University of Florida, and the Veterans Administration Medical Center Gainesville, Florida, USA
Correspondence to:
1Current address and correspondence to: Dr Howard Poizner, Center for Molecular and Behavioral Neuroscience, Rutgers University, 195 University Avenue, Newark, NJ 07102, USA.
The left cerebral hemisphere in man contains anatomical structures specialized not only for language but also for higher-order motor programming. One method of studying the nature of these motor programs is by observing the type of errors made by patients who have left hemisphere damage. A major problem, however, in investigating the disorders that result from failure of this specialized left hemisphere system (the apraxias) has been the difficulty in obtaining objective measurement of movement in three-dimensional space. To this end, we provide the first three-dimensional analysis of the nature of movement errors in apraxia. Two apraxic subjects with lesions to the left hemisphere and 5 matched control subjects were studied. The apraxic subjects showed impairments in the control of movement timing and spatial relations, as well as decoupling in the normally tight relation between certain spatial and temporal aspects of their movement trajectories. Further, the use of the distal musculature by apraxic subjects was more impaired than their use of the proximal musculature, suggesting more distal representation in any space-time maps of learned movement. These data provide further insight into the nature of the representations of learned skilled movements in the left cerebral hemisphere.
Received October 11, 1988. Revised March 7, 1989. Accepted March 31, 1989.
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