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Brain, Vol. 113, No. 2, 487-496, 1990
© 1990 Oxford University Press

research-article

OPTIC NEURITIS: VARIATIONS IN TEMPORAL MODULATION SENSITIVITY WITH RETINAL ECCENTRICITY

GRAHAM K. EDGAR1,, DAVID H. FOSTER2,, WILLIAM P. HONAN2,3, JAMES R. HERON2,3 and ROSEMARY S. SNELGAR1

1Department of Communication and Neuroscience Staffordshire 2Department of Postgraduate Medicine, University of Keele Staffordshire 3Department of Neurology, North staffordshire Royal Infirmary Stock-on-Trent, UK

Correspondence to: Correspondence to: Professor David H. Foster, Department of Communication and Neuroscience, University of Keele, Keele, Staffordshire ST5 5BG, England.

Temporal modulation sensitivity functions were measured centrally and at eccentricities of 2.5°, 5° and 10° in the temporal visual field of 12 patients with recovered optic neuritis and in a group of matched normal controls. A circular, spatially uniform stimulus of 1° angular subtense was presented with sinusoidal modulation at 5, 8, 14 and 23 Hz. The general pattern of results in patients was a loss of sensitivity relative to normal controls at all temporal frequencies at 0° and 2.5° eccentricity, with rather greater losses occurring at the medium-to-lower temporal frequencies. At 5° eccentricity, the losses were confined to medium temporal frequencies only, and at 10° eccentricity there was no significant loss at any temporal frequency. These findings may be explained by a greater vulnerability of optic nerve fibres of small diameter to the effects of demyelinating disease.

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Received July 29, 1988. Revised May 16, 1989. Accepted June 9, 1989.

Present addresses: Dr Graham K. Edgar, School of Psychology, University of Wales College of Cardiff, Cardiff CFI 3YG; Dr Rosemary S. Snelgar, Department of Psychology, University of Bristol, Bristol BS8 1HH.


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