Brain, Vol. 113, No. 3, 749-766, 1990
© 1990 Guarantors of Brain
research-article |
TROUBLED LETTERS BUT NOT NUMBERS: DOMAIN SPECIFIC COGNITIVE IMPAIRMENTS FOLLOWING FOCAL DAMAGE IN FRONTAL CORTEX
Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, The University of Iowa College of Medicine lowa City, Iowa, USA
Correspondence to:
Correspondence to: Dr Steven W. Anderson, Division of Behavioral Neurology and Cognitive Neuroscience, Department of Neurology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
A well educated right-handed woman developed severe and stable alexia and agraphia following a circumscribed surgical lesion in the left premotor cortex. The lesion was located in Brodmann's field 6, above Broca's area, in the region traditionally referred to as Exner's area. The alexia and agraphia occurred in a pure form, that is, in the setting of otherwise normal cognitive and neurological function. She was not aphasic or hemiparetic and her visual perception, intellect, memory, oral spelling and drawing were normal. The patterns of impairment of reading and writing closely paralleled one another. Reading of single words and letters was severely impaired, and she was entirely unable to read sentences. She was virtually unable to write recognizable letters, could write no words, and her writing attempts were severely distorted spatially. By contrast, she could easily read all numbers and nonverbal symbols, and she was equally able to write numbers and perform written calculations without difficulty. These striking dissociations provide further evidence of the domain specificity of cognitive/neural representations. They also point to the possible role of premotor cortices in the coactivation of precise sequences of motor and sensory activity patterns involved in reading and writing.
Received August 31, 1988. Revised March 21, 1989. Accepted July 11, 1989.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Longcamp, C. Boucard, J.-C. Gilhodes, J.-L. Anton, M. Roth, B. Nazarian, and J.-L. Velay Learning through Hand- or Typewriting Influences Visual Recognition of New Graphic Shapes: Behavioral and Functional Imaging Evidence. J. Cogn. Neurosci., May 1, 2008; 20(5): 802 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. -E. Roux, V. Lubrano, V. Lauwers-Cances, C. Giussani, and J. -F. Demonet Cortical areas involved in Arabic number reading Neurology, January 15, 2008; 70(3): 210 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bonoti, F. Vlachos, and P. Metallidou Writing and Drawing Performance of School Age Children: Is There Any Relationship? School Psychology International, May 1, 2005; 26(2): 243 - 255. [Abstract] [PDF]
|
|
|
|
 |
|
 F.-E. Roux, V. Lubrano, V. Lauwers-Cances, M. Tremoulet, C. R. Mascott, and J.-F. Demonet Intra-operative mapping of cortical areas involved in reading in mono- and bilingual patients Brain, August 1, 2004; 127(8): 1796 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Fulbright, D. L. Molfese, A. A. Stevens, P. Skudlarski, C. M. Lacadie, and J. C. Gore Cerebral Activation during Multiplication: A Functional MR Imaging Study of Number Processing AJNR Am. J. Neuroradiol., June 1, 2000; 21(6): 1048 - 1054. [Abstract] [Full Text]
|
|
|
|
|
|
F. Chochn, L. Cohen, P. F. v. d. Moortele, and S. Dehaene Differential Contributions of the Left and Right Inferior Parietal Lobules to Number Processing J. Cogn. Neurosci., November 1, 1999; 11(6): 617 - 630. [Abstract] [Full Text]
|
|