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Brain, Vol. 113, No. 5, 1347-1359, 1990
© 1990 Guarantors of Brain

research-article

MAGNETIC SOURCE LOCALIZATION IN FOCAL EPILEPSY

MULTICHANNEL MAGNETOENCEPHALOGRAPHY CORRELATED WITH MAGNETIC RESONANCE BRAIN IMAGING

H. STEFAN1,, S. SCHNEIDER4, K. ABRAHAM-FUCHS4, J. BAUER1, H. FEISTEL3, G. PAWLIK5, U. NEUBAUER2, G. RÖOHRLEIN4 and W. J. HUK2

1Department of Neurology, University of Erlangen Nürnberg 2Department of Neurosurgery, University of Erlangen Nürnberg 3Department of Nuclear Medicine, University of Erlangen Númberg 4Max-Planck Institute for Neurological Research Cologne 5Siemens Medical Engineering Group Erlangen, FRG

Correspondence to: Correspondence to: Professor H. Stefan, Neurologische Klinik mit Poliklinik. Schwabachanlage 6, 8520 Erlangen, FRG.

Initial results of magnetic source localization by means of multichannel recording using a 10 or a 31 channel system are reported. Simultaneous magnetoencephalographic (MEG) and electroencephalographic (EEG) (scalp, sphenoidal and foramen ovale) recording, as well as magnetic resonance imaging (MRI) with a fixed head position, permits the projection of brain structures and the source localized from MEG into a three-dimensional coordinate system. From 8 patients investigated it can be clearly seen that the method is of diagnostic relevance for patients with temporal lobe epilepsy. Results are demonstrated for 3 patients with interesting findings concerning the anatomical correlation with source localization. The findings indicate that MRI-correlated magnetic source localization by means of multichannel recordings provides important advantages in epilepsy research. (1) Increased precision permits noninvasive localization. Deeper sources in the temporal lobe are localized from MEG combined with scalp or minor invasive EEG. (2) Investigation time is considerably shortened. (3) Single events can be localized for supplementary presurgical information concerning the three-dimensional anatomical localization of focal epileptic activity in the brain.

Received February 14, 1989. Revised August 18, 1989. Accepted October 16, 1989.


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