Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (73)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by GOADSBY, P. J.
Right arrow Articles by ZAGAMI, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GOADSBY, P. J.
Right arrow Articles by ZAGAMI, A. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 114, No. 2, 1001-1011, 1991
© 1991 Oxford University Press

research-article

STIMULATION OF THE SUPERIOR SAGITTAL SINUS INCREASES METABOLIC ACTIVITY AND BLOOD FLOW IN CERTAIN REGIONS OF THE BRAINSTEM AND UPPER CERVICAL SPINAL CORD OF THE CAT

P. J. GOADSBY and A. S. ZAGAMI

Department of Neurology, The Prince Henry and Prince of Wales Hospitals, and School of Medicine, University of New South Wales Sydney, Australia

Correspondence to: Correspondence to: Dr P.J.Goadsby, Department of Neurology, The Prince Henry Hospital, Little Bay, Sydney NSW 2036, Australia.

To investigate the anatomical distribution of cells concerned with relaying craniovascular nociception, local cerebral blood flow was examined in the cat using the tracer [14C]-iodoantipyrine and local cerebral glucose utilization determined by the 2-deoxyglucose method in tissue autoradiographs. The superior sagitial sinus was stimulated electrically and its effect on caudal brainstem and upper cervical spinal cord blood flow and metabolism evaluated. This caused increased metabolic activity and blood flow in the trigeminal nucleus caudalis, in the cervical dorsal horn and in a discrete area in the dorsolateral spinal cord at the second cervical segment. Responses in these 3 areas were blocked by ablation of the trigeminal ganglia. The dorsolateral area activated in the spinal cord corresponds to a group of cells in or near the lateral cervical nucleus that may form an important relay for craniovascular nociception and thus be of relevance to the mechanism of headache.

Received December 28, 1989. Revised June 5, 1990. Accepted June 26, 1990.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
T. Bartsch and P. J. Goadsby
Increased responses in trigeminocervical nociceptive neurons to cervical input after stimulation of the dura mater
Brain, August 1, 2003; 126(8): 1801 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
I Schindler, G Kerkhoff, H-O Karnath, I Keller, and G Goldenberg
Neck muscle vibration induces lasting recovery in spatial neglect
J. Neurol. Neurosurg. Psychiatry, October 1, 2002; 73(4): 412 - 419.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
B. J. Sessle
Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates
Critical Reviews in Oral Biology & Medicine, January 1, 2000; 11(1): 57 - 91.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.