Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BOTEZ, M. I.
Right arrow Articles by YOUNG, S. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOTEZ, M. I.
Right arrow Articles by YOUNG, S. N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 114A, No. 1, 333-348, 1991
© 1991 Oxford University Press

EFFECTS OF ANTICONVULSANT TREATMENT AND LOW LEVELS OF FOLATE AND THIAMINE ON AMINE METABOLITES IN CEREBROSPINAL FLUID

M. I. BOTEZ and S. N. YOUNG

Neurology Service, Department of Medicine, Hôtel Dieu Hospital University of Montreéeal Department of Psychiatry, McGill University Montréal, Canada

Correspondence to: Correspondence to: Dr M. I. Botez, Hôtel Dieu Hospital, 3840 rue St Urbain, Montréal, Quebec, Canada H2W 1T8

A total of 157 epileptic patients were studied with respect to (1) biogenic amine precursors and metabolites in the CSF, (2) levels of folate and thiamine in the blood and CSF, (3) length of treatment with phenytoin (PHT), (4) PHT intoxication, (5) CNS atrophy. Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy. PHT intoxication increased CSF 5-hydroxyindoleacetic acid (5HIAA). Low folate levels were associated with decreased CSF 5HIAA and homovanillic acid, while low thiamine levels were associated with decreased CSF 5HIAA and 3-methyoxy-4-hydroxyphenylethylene glycol. It remains to be seen to what extent these alterations in biogenic amine metabolism, mediated by low CNS vitamin levels, also lead to deficits in cerebral function.

Received July 27, 1988. Revised March 16, 1990. Accepted March 30, 1990.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.