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Brain, Vol. 115, No. 6, 1611-1631, 1992
© 1992 Guarantors of Brain

research-article

INTERACTIONS BETWEEN OLIGODENDROCYTES AND MICROGLIA

A MAJOR ROLE FOR COMPLEMENT AND TUMOUR NECROSIS FACTOR IN OLIGODENDROCYTE ADHERENCE AND KILLING

J. P. ZAJICEK1, M. WING2, N. J. SCOLDING1 and D. A. S. COMPSTON1

1University of Cambridge Neurology unit Cambridge, UK 2Molecular Immunopathology Unit, MRC Centre Addenbrookes Hospital Cambridge, UK

Correspondence to: Correspondence to: J. P. Zajicek, University of Cambridge Neurology unit, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK.

Interactions between rat microglia and oligodendrocytes were examined in vitro in order to characterize the stages of adherence, phagocytosis and cytotoxicity against oligodendrocytes by microglia. Under resting conditions, microglia showed minimal contact with oligodendrocytes and exhibited surface staining of myelin basic protein and myelin debris only; they were not cytotoxic for oligodendrocytes and did not produce tumour necrosis factor (TNF). On activation with either {Gamma}-interferon or lipopolysaccharide and interferon, these cells increased surface binding for myelin basic protein, showed greater contact with living oligodendrocytes and produced TNF in both secreted and cell surface bound forms. Secreted TNF was capable of killing oligodendrocytes but the cell surface bound form did this more efficiently. In the presence of complement, activated microglia showed significant phagocytosis of myelin basic protein which was not obvious in the unactivated cells. These results suggest that activated microglia in the presence of complement are sufficient to kill and phagocytose the oligodendrocyte-myelin complex in vitro

Received April 13, 1992. Revised June 8, 1992. Accepted June 16, 1992.


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