Brain, Vol. 116, No. 1, 267-279, 1993
© 1993 Oxford University Press
research-article |
Thalamic stimulation and suppression of parkinsonian tremor
Evidence of a cerebellar deactivation using positron emission tomography
1CERMEP PET Unit Lyon 2Department of Clinical and Biological Neurosciences, INSERM U318 Grenoble, France 3MRC Cyclotron Unit, Hammersmith Hospital London 4Department of Experimental Psychology, Oxford University Oxford, UK
Correspondence to:
Correspondence to: Dr Marie-Peirre Deiber, CERMEP, Centre d'Exploration et de Recherche Médicales par Emission de Positions. 59 Boulevard Pinel, 69003 Lyon, France.
Parkinsonian tremor can be abolished by chronic high frequency thalamic stimulation of the ventral intermediate nucleus. We have studied six patients with unilateral Parkinson's disease. The patients had an electrode chronically implanted in the ventral intermediate nucleus of the thalamus. We measured changes in cerebral activity by positron emission tomography using an index of regional cerebral blood flow (rCBF). Each patient was scanned in three states: (i) tremor without stimulation (condition A); (ii) tremor with ineffective stimulation (condition B); (iii) tremor abolished by effective stimulation (condition C). The suppression of tremor (C compared with B) was specifically associated with a decrease of rCBF in the cerebellum, whereas the ineffective stimulation (B compared with A) induced a decrease of rCBF in homolateral cerebral cortex. The results give evidence for different contributions from cortex and cerebellum to the generation of parkinsonian tremor and suggest that tremor suppression is mainly associated with a decrease of synaptic activity in the cerebellum.
Received March 4, 1992. Revised September 21, 1992. Accepted September 28, 1992.
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