Brain, Vol. 116, No. 3, 569-602, 1993
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research-article |
A serial study of psychometric and magnetic resonance imaging changes in multiple sclerosis
1Departments of Neuropsychiatry London, UK 2Departments of Neurology, The Insitute of Neurology London, UK
Correspondence to:
Correspondence to: Dr Anthony Feinstein, Hospital, Denmark Hill, London SE5 8A2, UK.
Over a 6-month period, five patients with early relapsing-remitting multiple sclerosis and five with long-standing, benign multiple sclerosis underwent serial psychometric testing and contrast enhanced magnetic resonance imaging of the brain at 2-weekly or monthly intervals, respectively. All patients were individually matched with healthy controls who completed the same psychometric battery at the same time intervals. As a group, multiple selerosis patients either made more errors or performed slower on all psychometric tasks than controls. In the control subjects and those patients with a stable brain lesion score, no consistent deterioration occurred in any test and the overall pattern was one of improvement over time commensurate with practice effects. However, patients with a deteriorating lesion score either showed a fall-off in performance on some psychometric tasks (patients2, 3) or else an impaired ability to improve with practice on certain tests of attention and information-processing speed (patient 10).
Received June 12, 1992. Revised September 18, 1992. Accepted November 7, 1992.
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