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Brain, Vol. 116, No. 3, 695-715, 1993
© 1993 Guarantors of Brain

research-article

Comprehension deficits elicited by electrical stimulation of Broca's area

Leonard Schäffler1, Hans O. Lüders1, Dudley S. Dinner1, Ronald P. Lesser1 and Gordon J. Chelune2

1Cleveland Clinis Epilepsy Program, Departments of Neurology Ohio, USA 2Section of Neuropsychology, Department of Psychiatry and Psychology, Cleveland Clinic Foundation, Cleveland Ohio, USA

Correspondence to: Correspondence to: Dr H. Lü ders, Department of Neurology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

We report on three patients with intractable focal seizures arising from the language dominant left hemisphere. In the work-up prior to surgical treatment, arrays of subdural electrodes were placed over the left temporal lobe and adjacent supra-Sylvian region. Electrical stimulation of the inferior frontal cortex language region (‘Broca's area’) produced marked interference with language output functions including speech arrest, slowing of oral reading, paraphasia and anomia. At some cortical language sites in this region cortical stimulation also produced language comprehension deficits, particularly in response to more complex auditory verbal instructions and visual semantic material. The severe impairment of comprehension verbal information was in clear contrast with ability to process non-verbal material, which was not affected.

Received July 13, 1992. Revised November 12, 1992. Accepted January 14, 1993.


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