Brain, Vol. 116, No. 4, 903-919, 1993
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Evidence of multiple memory systems in the human brain
A [18F]FDG PET metabolic study
1INB CNR and University of Milan, Scientific Institute H. San Raffaele Italy 2University of Brescia Italy 3University of Rome Italy 4University of Rome Tor Vergata Italy 5University of Padua Italy
Correspondence to:
Correspondence to. Professor Ferruccio Fazio, Department of Nuclear Medicine, University of Milan, Scientific Institute H. San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Patients with global amnesia of different aetiologies (n = 11), and patients with probable Alzheimer's disease of recent onset and mild to moderate severity (n = 18) underwent extensive neuropsychological examination, which included the evaluation of multiple components of memory, and a measurement of regional cerebral glucose metabolism with [18F)fluoro-deoxyglucose (18F(FDG) and PET. In the neuropsychological tests, both global amnesia and Alzheimer's disease patients had impaired episodic long-term memory, while deficits of short-term, semantic and implicit memory were present only in Alzheimer's disease. When local metabolic rates for glucose were compared with values from age-and education-matched normal controls, a common pattern of bilateral hypometabolism was present in the hippocampus, cingulate and frontal basal cortex of both global amnesia and Alzheimer's disease patients. On the other hand, significant hypometabolism was found in the thalamus in only global amnesia, and in the frontal, parietal and temporal associative cortex in only Alzheimer's disease. The results of a multivariate regression analysis of test scores with metabolic data indicated that different clusters of cerebral areas were associated with each of the main components of memory function. These data are in agreement with ‘neural network’ models of the neural basis of cognition, according to which complex functions are subserved by multiple interconnected cortical and subcortical structures.
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Received September 14, 1992. Revised January 6, 1993. Accepted February 26, 1993.
*Present address Department of Psychology, Institute of Neurology, Queen Square, London WCIN 3BG, UK.
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