Brain, Vol. 116, No. 4, 921-940, 1993
© 1993 Guarantors of Brain
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Autobiographical nokamnesia resulting from bilateral paramedian thalamic infarction
A case study in cognitive neurobiology
1University of Cambridge Neurology unit Cambridge, UK 2Department of Experimental Psychology Cambridge, UK
Correspondence to:
Correspondence to: Dr J R. Hodges, Department of Neurology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
A patient with a chronic amnesic state resulting from bilateral paramedian thalamic infarction showed a pattern of retrograde amnesia not previously reported. Personally relevant autobiographical memory was profoundly impaired, whereas knowledge of famous people and public events was relatively spared. Furthermore, knowledge of famous people, including the ability to make accurate temporal judgements, was less affected than knowledge of public events. In addition, we have documented a severe and systematic distortion of personal memory. These findings are not compatible with current accounts of retrograde amnesia based either upon the type of information stored (e.g. episodic versus semantic memory), or upon simple storage versus access models. We propose and explanation based upon an interactive cognitive model in which the patient shows a disorder at the ‘thematic retrieval framework’ level of memory organization due to a disconnection of frontal and medial temporal memory systems.
Received November 4, 1992. Revised January 14, 1993. Accepted January 25, 1993.
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