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Brain, Vol. 116, No. 5, 1059-1075, 1993
© 1993 Guarantors of Brain

research-article

The neurotrophic analogue of ACTH(4–9), Org 2766, protects against experimental allergic neuritis

H. J. Duckers, J. Verhaagen and W. H. Gispen

Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht The Netherlands

Correspondence to: Correspondence to Professor Dr W H. Gispen, Rudolf Magnus Institute, Vondellaan 6, 3521 GD Utrecht, The Netherlands

Demyelinating diseases such as multiple sclerosis or the Guillain-Barré syndrome originate from an autoimmune response resulting in the degradation of myelin and impaired neuronal function. Prophylactic administration of the neurotrophic peptide, H-Met(O2)-Glu-His-Phe-D-Lys-Phe-OH (an ACTH(4–9) analogue), to rats with experimental allergic neuritis, a model for the Guillain-Barré syndrome, markedly suppresses the clinical symptoms, protects against loss of motor coordination and prevents the degeneration of myelinated axons in the affected peripheral nerve. Therefore, this peptide may provide a new approach to the therapy of peripheral demyelinating polyneuropathies.

Received November 12, 1992. Revised February 8, 1993. Accepted May 4, 1993.


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