Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lewis, R. F.
Right arrow Articles by Zee, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lewis, R. F.
Right arrow Articles by Zee, D. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol. 116, No. 5, 1105-1118, 1993
© 1993 Guarantors of Brain

research-article

Abnormal spatial localization with trigeminal-oculomotor synkinesis

Evidence for a proprioceptive effect

Richard F. Lewis and David S. Zee

Department of Neurology, Johns Hopkins University School of Medicine Baltimore, Maryland, USA

Correspondence to: Correspondence to Dr David Zee, Department of Neurology, Pathology 2-210, 600 N. Wolfe Street, Baltimore, MD 21287-6921, USA

We examined spatial localization, using open-loop pointing to visual targets, in a patient with a congenital trigeminal-oculomotor synkinesis. This patient demonstrated abnormal co-activation of the left medial rectus muscle when the left lateral pterygoid contracted. Because one eye could be deviated in the absence of a normal oculomotor innervational command, the efference copy (derived from monitoring of central oculomotor commands) could be dissociated from the proprioceptive afferent signal (determined by the mechanical state of the extraocular muscles). Under conditions of monocular viewing with the normal right eye, when the covered left eye was adducted by the aberrant trigeminal innervation, the patient pointed to the left of the actual position of the target. This finding indicates that proprioceptive afference from the adducted, covered left eye was used in the process of spatial localization.

While synkinetic adduction produced a shift in pointing in the opposite direction of rotation of the non-viewing eye, previous studies using passive deviation of the non-viewing eye in normal subjects reported a shift in pointing in the same direction as eye rotation (Gauthier et al., 1990; Bridgeman and Stark, 1991). We propose that this discrepancy is due to the different effects of passive eye rotation and active muscle contraction on the tendon organs of the extraocular muscles. On this basis, we hypothesize that the tendon organs, rather than the muscle spindles, are primarily responsible for the transduction of proprioceptive information about eye position in the orbit.

Received January 6, 1993. Revised May 4, 1993. Accepted May 25, 1993.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. F. Lewis, B. M. Gaymard, and R. J. Tamargo
Efference Copy Provides the Eye Position Information Required for Visually Guided Reaching
J Neurophysiol, September 1, 1998; 80(3): 1605 - 1608.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.