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Brain, Vol. 116, No. 6, 1387-1398, 1993
© 1993 Guarantors of Brain

research-article

Both primary motor cortex and supplementary motor area play an important role in complex finger movement

Hiroshi Shibasaki1, Norihiro Sadato2, Hugh Lyshkow1, Yoshiharu Yonekura1, Manabu Honda1, Takashi Nagamine1, Shugo Suwazono1, Yasuhiro Magata2, Akio Ikeda1, Masahito Miyazaki1, Hidenao Fukuyama3, Renin Asato2 and Junji Konishi2

1Department of Brain Pathophysiology Kyoto, Japan 2Department of Nuclear Medicine Kyoto, Japan 3Department of Neurology, Kyoto University School of Medicine Kyoto, Japan

Correspondence to: Correspondence to: Hiroshi Shibasaki, MD, Department of Brain Pathophysiology, Kyoto University School of Medicine, Shogoin, Sakyo, Kyoto 606–01, Japan.

In order to clarify the roles played by the primary motor cortex and the supplementary motor area in the execution of complex sequential and simple repetitive finger movements, regional cerebral blood flow (rCBF) was measured with PET using 15O-labelled water in five normal subjects. The PET data of each individual subject co-registered to his own MRI, was analysed. Compared with the resting condition, the mean rCBF was markedly increased in the contralateral sensorimotor cortex (MI-SI) and moderately increased in the contralateral cingulate gyrus and putamen in both the simple and complex motor tasks. During the complex motor task, in addition to the above, the mean rCBF was markedly increased in the supplementary motor area and the contralateral premotor area, and moderately increased in the ipsilateral M1-S1 and cerebellum. In the supplementary motor area, there was a moderate rCBF increase also during the simple task. However, comparison of the mean rCBF increase against the resting condition between the two tasks revealed a greater increase during the complex task than in the other only in the supplementary motor area and the ipsilateral M1-S1. Thus, in agreement with our previous electrophysiological findings, not only the supplementary motor area but also the M1-S1 seems to play an important role in the execution of complex sequential finger movements.

Received April 7, 1993. Revised July 21, 1993. Accepted September 1, 1993.


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