Brain, Vol. 117, No. 1, 27-38, 1994
© 1994 Oxford University Press
research-article |
Electromyographic features of levator palpebrae superioris and orbicularis oculi muscles in blepharospasm
1The Graduate School of Neurosciences in the University of Amsterdam, Faculty of Medicine, Department of Neurology Amsterdam, The Netherlands 2The Graduate School of Neurosciences in the University of Amsterdam, Faculty of Medicine, Division of Clinical Neurophysiology, Academic Medical Centre Amsterdam, The Netherlands 3The Graduate School of Neurosciences in the University of Amsterdam, Faculty of Medicine, Facial Research, Academic Medical Centre Amsterdam, The Netherlands
Correspondence to:
Correspondence to: Dr M. Aramideh, Department of Neurology and Clinical Neurophysiology (H2-214), Academic Medical Centre, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands
Electromyographic (EMG) recording was performed synchronously from the levator palpebrae superioris (LP) and the orbicularis oculi (OO) muscles in 28 patients referred to us for treatment of blepharospasm with botulinum A toxin. At the time of this study, 19 patients were under the treatment with botulinum, four started treatment shortly after the EMG recording and five patients had not yet been treated. Based on the EMG patterns, we were able to classify five major groups of abnormalities. Group 1 (blepharospasm): consisted of 10 patients with dystonic discharges limited to OO, normal LP tonic activity, intact reciprocal inhibition between LP and OO and dense bursts of action potentials with high amplitude preceding the return of LP tonic activity, i.e. ‘postinhibition potentiation’ of LP, brought about by a brief contraction of OO. Group 2 (combined dystonic activities of LP and OO): seven patients belonged to this group. The EMG recording revealed alternating tremulous discharges in both LP and OO muscles, and short intervals of co-contractions due to moderately disturbed reciprocal inhibition. Group 3 (combination of blepharospasm, LP motor impersistence): the EMG patterns, observed in three patients, were characterized by a gradual cessation of LP activity, followed by a brief contraction of OO, which facilitated the return of LP activity, resulting in opening of the eyes. The EMG recordings, thus, revealed the crucial, beneficial role of postinhibition potentiation as a compensatory mechanism in this type of eyelid movement disorder. The EMG patterns were also characterized by short or prolonged periods of dystonic discharges limited to the OO muscles. Group 4 (combination of blepharospasm, involuntary LP inhibition): this group consisted of four patients. In addition to episodes of dystonic activities of OO, the EMG also showed some periods of involuntary inhibition of LP without any concomitant activities of OO. Two patients also exhibited a failure of inhibition of OO muscle activity, following the voluntary contraction of this muscle. The postinhibition potentiation was often not observed. Group 5 (involuntary LP inhibition): consisted of four patients with EMG patterns of involuntary inhibition of LP activity, without any dystonic discharges in OO. The postinhibition potentiation was not observed in this group. The response to the treatment with botulinum toxin was good in the first group and gradually worsened towards the fifth group. Application of botulinum into multiple sites of OO, especially its pretarsal portion, resulted in better response to the treatment in the second and fourth groups. We conclude that synchronous EMG recording of LP and OO is an indispensable investigation method to establish the origin of varying forms of eyelid movement disorders in patients with clinical symptoms of blepharospasm, and to analyse the cause of unsatisfactory response to the treatment with botulinum.
dystonia; blepharospasm; levator palpebrae inhibition; involuntary eyelid closure; EMG
Received August 3, 1993. Revised September 21, 1993. Accepted September 25, 1993.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Bologna, R. Agostino, B. Gregori, D. Belvisi, D. Ottaviani, C. Colosimo, G. Fabbrini, and A. Berardelli Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy Brain, February 1, 2009; 132(2): 502 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. VanderWerf, P. Brassinga, D. Reits, M. Aramideh, and B. Ongerboer de Visser Eyelid Movements: Behavioral Studies of Blinking in Humans Under Different Stimulus Conditions J Neurophysiol, May 1, 2003; 89(5): 2784 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Forget, V. Tozlovanu, A. Iancu, and D. Boghen Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening Neurology, June 25, 2002; 58(12): 1843 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Aramideh, J H T M Koelman, P P Devriese, J D Speelman, and B W Ongerboer de Visser Thixotropy of levator palpebrae as the cause of lagophthalmos after peripheral facial nerve palsy J. Neurol. Neurosurg. Psychiatry, May 1, 2002; 72(5): 665 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tozlovanu, R. Forget, A. Iancu, and D. Boghen Prolonged orbicularis oculi activity: A major factor in apraxia of lid opening Neurology, September 25, 2001; 57(6): 1013 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Bour, M. Aramideh, and B. W. Ongerboer de Visser Neurophysiological Aspects of Eye and Eyelid Movements During Blinking in Humans J Neurophysiol, January 1, 2000; 83(1): 166 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P Campbell, D. A Williams, B. R Frueh, and G. S Lynch Contractile activation characteristics of single permeabilized fibres from levator palpebrae superioris, orbicularis oculi and vastus lateralis muscles from humans J. Physiol., September 1, 1999; 519(2): 615 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Deuschl and C. Goddemeier Spontaneous and reflex activity of facial muscles in dystonia, Parkinson's disease, and in normal subjects J. Neurol. Neurosurg. Psychiatry, March 1, 1998; 64(3): 320 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Hasan, R. S. Baker, W. S. Sun, B. R. Rouholiman, J. C. Chuke, D. E. Cowen, and J. D. Porter The Role of Blink Adaptation in the Pathophysiology of Benign Essential Blepharospasm Arch Ophthalmol, May 1, 1997; 115(5): 631 - 636. [Abstract] [PDF]
|
|