Brain, Vol. 118, No. 6, 1411-1419, 1995
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Functional MRI measurement of language Lateralization in Wada-tested patients
1Departments of Radiology, Stanford University Stanford, USA 2Departments of Neurology, Stanford University Stanford, USA 3Departments of Psychology, Stanford University Stanford, USA 4Departments of Psychiatry and Behavioral Sciences, Stanford University Stanford, USA
Correspondence to:
Correspondence to: John E. Desmond, Department of Psychology, Stanford University, Stanford, CA 94305, USA
In this study the use of functional MRI (fMRI) for measuring language lateralization non-invasively was examined. The subjects were seven patients with histories of temporal lobe epilepsy who had undergone Wada resting for pre-surgical evaluation. Four patients were left-hemisphere-dominant and three were right-hemisphere-dominant for language. They received fMRI scans while they made semantic or perceptual judgments about visually presented words. Regions of the inferior frontal gyrus (pars triangularis and pars orbitalis) and neighbouring orbital cortex, corresponding to portions of Brodmann areas 45, 46 and 47, exhibited significant increases in activation during semantic relative to perceptual judgments. Lateralization of the increases in activation were consistent with the Wada test assessments of hemispheric language dominance in each of the seven patients. These results suggest that, in addition to providing a tool for investigating human cognitive processes, fMRI has significant clinical potential as a non-invasive measure of language laterlization.
language lateralization; functional MRI; Wada test; epilepsy; hemispheric dominance
Received February 17, 1995. Revised July 11, 1995. Accepted July 21, 1995.
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|
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|
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|
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|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S. Gilman Imaging the Brain- First of Two Parts N. Engl. J. Med., March 19, 1998; 338(12): 812 - 820. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J. F. Brinkley and C. Rosse The Digital Anatomist Distributed Framework and Its Applications to Knowledge-based Medical Imaging J. Am. Med. Inform. Assoc., May 1, 1997; 4(3): 165 - 183. [Abstract] [Full Text] [PDF]
|
|