Brain, Vol. 119, No. 1, 159-179, 1996
© 1996 Oxford University Press
research-article |
Noun and verb retrieval by normal subjects Studies with PET
1MRC Clinical Science Centre, Cyclotron Unit, Hammersmith Hospital London, UK 2Academic Department of Neurosciences, Charing Cross and Westminster Medical School London, UK 3Neurologische Klinik und Poliklinik, Universitatsklinikum Essen Hufelandstraße 55, 45122, Essen, Germany 4Department of Psychology, Tel Aviv University Ramat Aviv, Israel 5Nuclear Medicine and Ultrasound Associates, The Ashley Centre Westmead, Australia
Correspondence to:
Dr Richard Wise, Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
PET activation studies identify significant local changes in regional cerebral blood flow (rCBF) in contrasts of behavioural tasks with control states, and these local changes identify net changes in local synaptic activity. A number of studies on word retrieval have all demonstrated left frontal (dorsolateral and medial) involvement in the task. However, there have been differences in the responses observed in the left temporal lobe, with variously a deactivation (significant decrease in rCBF), no response and an activation (significant increase in rCBF). In the four studies described here, we have examined word (verbs and nouns) retrieval contrasted with a number of different control states. The studies confirmed extensive activation of the left dorsolateral prefrontal cortex and, medially, the anterior cingulate cortex and the supplementary motor area (SMA). Activations of the left posterior temporal lobe and the inferior parietal lobe were consistently demonstrated when word retrieval was contrasted with a rest state. Contrasts with other single word tasks controlled out the activation in the perisylvian part of the left posterior temporal lobe, suggesting a role for this region in lexical processing. The left inferolateral temporal cortex and the posterior part of the inferior parietal lobe were only activated by word retrieval, particularly verbs. It is proposed that these activated regions reflect access to semantic fields.
PET; word retrieval; verbs; nouns
Received May 18, 1995. Revised July 10, 1995. Accepted September 1, 1995.
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