Brain, Vol. 119, No. 4, 1221-1238, 1996
© 1996 Guarantors of Brain
research-article |
Cerebral organization of component processes in reading
1Departments of Pediatrics, Yale University School of Medicine USA 2Departments of Neurology, Yale University School of Medicine USA 3Departments of Diagnostic Radiology, Yale University School of Medicine USA 4Departments of Haskins Laboratories, Yale University USA 5Department of Applied Physics, Yale University USA 6Department of Pediatrics, University of Texas-Houston School of Medicine USA 7Department of Psychology, University of Connecticut USA
Correspondence to:
Correspondence to: Kenneth R. Pugh, Department of Pediatrics, Yale University School of Medicine, PO Box 3333, New Haven, CT 06510–8064, USA
The cerebral organization of word identification processes in reading was examined using functional magnetic resonance imaging (fMRI). Changes in fMRI signal intensities were measured in 38 subjects (19 males and 19 females) during visual (line judgement), orthographic (letter case judgement), phonological (nonword rhyme judgement) and semantic (semantic category judgement) tasks. A strategy of multiple subtractions was employed in order to validate relationships between structure and function. Orthographic processing made maximum demands on extrastriate sites, phonological processing on a number of frontal and temporal sites, and lexical-semantic processing was most strongly associated with middle and superior temporal sites. Significant sex differences in the cerebral organization of reading-related processes were also observed.
fMRI; reading; phonology; orthography; semantic processing
Received December 8, 1995. Revised February 23, 1996. Accepted March 26, 1996.
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