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Brain, Vol. 119, No. 4, 1249-1253, 1996
© 1996 Guarantors of Brain

research-article

Bilateral simultaneous transcranial Doppler monitoring of flow velocity changes during visuospatial and verbal working memory tasks

Letizia M. Cupini1,, Maria Matteis2, Elio Troisi2, Maurizio Sabbadini2, Giorgio Bernardi1,2, Carlo Caltagirone1 and Mauro Silvestrini1

1Clinic of Neurology, S. Eugenio Hospital-University of Rome ‘Tor Vergata’ Rome, Italy 2IRCCS ‘S. Lucia’ Rome, Italy

Correspondence to: Correspondence to: Dr L. M. Cupini, Clinica Neurologica Università di Roma ‘Tor Vergata’, Ospedale S. Eugenio, P.le dell'Umanesimo 10, 00144 Roma, Italy

Twenty-two normal volunteers were studied by simultaneous bilateral transcranial Doppler (TCD) monitoring of flow velocity changes in the middle cerebral arteries during visuospatial and verbal working memory tasks. All tasks were visually presented material; they required full engagement of subjects during the study, similar attention demands and a manual response when the appropriate target was recognized. Stimuli were presented tachistoscopically. Each task produced significant and distinct effects on flow velocity with respect to baseline values. When side-to-side comparisons were performed, a significantly higher increase in flow velocity was observed in the right middle cerebral artery (MCA) compared with the left one during the visuospatial task (P<0.005). Our findings agree with results of recent studies using PET which show lateralized activation during working memory tasks. The high temporal resolution of this technique suggests that further application in cerebral flow change monitoring during neuropsychological studies could be promising.

transcranial Doppler; working memory

Received January 5, 1996. Revised March 6, 1996. Accepted March 23, 1996.


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