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Erratum for Davie et al., Brain 118 (6) 1583-1592.
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Brain, Vol. 119, No. 4, 1415, 1996
© 1996 Guarantors of Brain

correction

Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss

C. A. Davie, G. J. Barker, S. Webb, P. S. Tofts, A. J. Thompson, A. E. Harding, W. I. McDonald and D. H. Miller

Summary

A consistent error has been discovered in the calculation of cerebellar volumes in the three patient groups and in the control group. The calculated cerebellar volumes should have been multiplied by the slice thickness of 3 mm and should therefore be three times the values stated in Tables 1–3. This does not affect the statistical values between the three groups of patients and the control group. In the ataxic multiple sclerosis group, there remains a highly significant reduction in the median cerebellar volume (median 107 865 mm2, range 101 574–131 421 mm2) compared with the control group 132 003 mm2, range 121 278–143 778 mm2, P = 0.0005). In contrast, the median cerebellar volume of multiple sclerosis patients who were clinically unaffected (median 128 037 mm2, range 112 008–135 750 mm2) showed no significant difference from the control group (P > 0.05). The patients with autosomal dominant cerebellar ataxia also showed a significant reduction in the median cerebellar volume (median 94 137 mm2, range 61 596–115 434 mm2, P - 0.0003) compared with the control group.


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H F McFarland, F Barkhof, J Antel, and D H Miller
The role of MRI as a surrogate outcome measure in multiple sclerosis
Multiple Sclerosis, February 1, 2002; 8(1): 40 - 51.
[Abstract] [PDF]


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