Brain, Vol. 119, No. 6, 2073-2083, 1996
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research-article |
Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval
1Wellcome Brain Research Group, School of Psychology, University of St Andrews St Andrews 2Wellcome Department of Cognitive Neurology, Institute of Neurology St Andrews 3Academic Department of Psychiatry, Royal Free Hospital School of Medicine London, UK
Correspondence to:
Correspondence to: M. D. Rugg, Wellcome Brain Research Group, School of Psychology, University of St Andrews, St Andrews KY16 9JU, UK
Six subjects underwent PET scans while they performed three versions of a recognition memory test for words and three versions of a control task. In each memory condition, the subjects discriminated between words presented in a prescan study list and words new to the experiment. During the 30 s scanning interval, the ratio of old and new words was 0: 20, 4: 16 or 16: 4, depending on the experimental condition. Outside this interval, the ratio was 50: 50 in all three conditions. The requirement in the control task was to discriminate between two character strings, the ratios of which were also manipulated during the 30 s scanning interval. Employing the control task as a covariate, analysis with statistical parametric mapping revealed that regional cerebral blood flow (rCBF) covaried with increasing density of old items in three regions of prefrontal cortex: right dorsolateral [Brodmann area (BA) 9/46], right medial (BA 32/8) and bilateral frontopolar cortex (BA 10). It is concluded that the prefrontal cortex, especially in the right hemisphere, is more active when a retrieval attempt succeeds than when it fails. This finding is consistent with the idea that the prefrontal cortex supports processes that operate selectively on the products of memory retrieval.
episodic memory; memory retrieval; prefrontal cortex; recognition memory
Received May 30, 1996. Accepted August 2, 1996.
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