Brain, Vol 120, Issue 1 15-26, Copyright © 1997 by Oxford University Press
J Foong, L Rozewicz, G Quaghebeur, CA Davie, LD Kartsounis, AJ Thompson, DH Miller and MA Ron
Deficits in executive function and the relationship to frontal lesion load
as detected on MRI were investigated in 42 multiple sclerosis patients. A
battery of neuropsychological test examining executive skills including
computerized tests of planning and spatial working memory was administered
to all subjects. Performance on these tests was impaired in the patient
group when compared with a group of matched controls, but not all executive
skills were affected to the same extent. Although a number of executive
test scores correlated with the severity of frontal lesion load, it was
difficult to disentangle the specific contribution of frontal lobe
pathology to the impairment on executive tasks. This study highlights the
difficulties in attempting to attribute specific cognitive abnormalities to
focal brain pathology in the presence of widespread disease such as in
multiple sclerosis.
ARTICLES
Executive function in multiple sclerosis. The role of frontal lobe pathology
Institute of Neurology, London, UK.
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