Brain, Vol 120, Issue 1 91-102, Copyright © 1997 by Oxford University Press
P Weiss, GE Stelmach and H Hefter
The execution of multiple-component movements has been shown to be impaired
in Parkinson's disease patients. To determine whether this deficit is
attributed to faulty motor programming, a two-segment movement was examined
by studying the kinematics of the first segment when the second segment
contained variable accuracy requirements. The performance of 15 Parkinson's
disease patients was compared with an age- matched control group. Movement
precision not only affected the kinematics of the final segment but also
the kinematics of the first segment. This 'context effect' was observed in
both groups. Since Parkinson's disease patients revealed similar movement
patterns to those of controls, their motor programming appears to be
intact. Furthermore, correlation analysis for the segment movement-times
revealed subjects with high as well as low correlation indices in both
groups. The correlation indices were related to the context effect only in
the Parkinson's disease patients. Independent of these phenomenon.
Parkinson's disease patients showed marked hesitations between the movement
segments compared with controls, suggesting that they have difficulty in
implementing and/or in switching between motor program steps. Impaired
force control and a reduced capacity to terminate movements in Parkinson's
disease are discussed as possible explanations of the deficit in motor
program implementation.
ARTICLES
Programming of a movement sequence in Parkinson's disease
Motor Control Laboratory, Arizona State University, Tempe, USA.
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