Brain, Vol 120, Issue 2 289-297, Copyright © 1997 by Oxford University Press
P Kujala, R Portin and J Ruutiainen
The purpose of this study was to illustrate how cognitive functioning
evolves over time in patients with multiple sclerosis. We followed the
evolution of cognitive performances in two clinically and demographically
similar multiple sclerosis groups, the 'cognitively preserved' (n = 20) and
the 'cognitively mildly deteriorated' (n = 22), and in healthy controls (n
= 34). We conducted the follow-up examination using the Mild Deterioration
Battery, the Mini-Mental State Examination, and a set of additional
neuropsychological measures after an interval of 3 years. The drop-out rate
in our study was only 5%. The 'cognitively preserved' multiple sclerosis
group showed substantial neuropsychological stability by performing as well
as the controls both at baseline and at follow-up. By contrast, the
initially 'cognitively mildly deteriorated' group demonstrated progressive
cognitive decline on many neuropsychological tests. The intermediate-length
screening battery, the Mild Deterioration Battery, was sensitive to this
decline, whereas the briefer Mini-Mental State Examination was not. The
progressive cognitive decline could not be predicted from other disease
variables. The study demonstrated that intact cognitive functioning in
multiple sclerosis may remain stable, whereas incipient cognitive decline
seems to be widespread and progressive in nature. Thus, progressive
cognitive deterioration should be considered as one of the characteristics
of multiple sclerosis.
ARTICLES
The progress of cognitive decline in multiple sclerosis. A controlled 3- year follow-up
Masku Neurological Rehabilitation Centre, Masku, Finland.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F Patti, M. Amato, M Trojano, S Bastianello, M. Tola, B Goretti, L Caniatti, E Di Monte, P Ferrazza, V Brescia Morra, et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study Multiple Sclerosis, July 1, 2009; 15(7): 779 - 788. [Abstract] [PDF]
|
|
|
|
|
|
G Koutsis, M Panas, E Giogkaraki, G Karadima, C Sfagos, and D Vassilopoulos An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis Multiple Sclerosis, February 1, 2009; 15(2): 174 - 179. [Abstract] [PDF]
|
|
|
|
|
|
F Patti Cognitive impairment in multiple sclerosis Multiple Sclerosis, January 1, 2009; 15(1): 2 - 8. [Abstract] [PDF]
|
|
|
|
|
|
B Duque, J Sepulcre, B Bejarano, L Samaranch, P Pastor, and P Villoslada Memory decline evolves independently of disease activity in MS Multiple Sclerosis, August 1, 2008; 14(7): 947 - 953. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Shi, C. B. Zhao, T. L. Vollmer, T. M. Tyry, and S. M. Kuniyoshi APOE {varepsilon}4 allele is associated with cognitive impairment in patients with multiple sclerosis Neurology, January 15, 2008; 70(3): 185 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Amato, E. Portaccio, B. Goretti, V. Zipoli, M. Battaglini, M. L. Bartolozzi, M. L. Stromillo, L. Guidi, G. Siracusa, S. Sorbi, et al. Association of Neocortical Volume Changes With Cognitive Deterioration in Relapsing-Remitting Multiple Sclerosis Arch Neurol, August 1, 2007; 64(8): 1157 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Sepulcre, S Vanotti, R Hernandez, G Sandoval, F Caceres, O Garcea, and P Villoslada Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test Multiple Sclerosis, April 1, 2006; 12(2): 187 - 195. [Abstract] [PDF]
|
|
|
|
 |
|
 S. J. Camp, V. L. Stevenson, A. J. Thompson, G. T. Ingle, D. H. Miller, C. Borras, B. Brochet, V. Dousset, M. Falautano, M. Filippi, et al. A longitudinal study of cognition in primary progressive multiple sclerosis Brain, December 1, 2005; 128(12): 2891 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G Lynch, B. A Parmenter, and D. R Denney The association between cognitive impairment and physical disability in multiple sclerosis Multiple Sclerosis, August 1, 2005; 11(4): 469 - 476. [Abstract] [PDF]
|
|
|
|
|
|
H Zephir, J de Seze, K Dujardin, G Dubois, M Cabaret, S Bouillaguet, D Ferriby, T Stojkovic, and P Vermersch One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis Multiple Sclerosis, June 1, 2005; 11(3): 360 - 363. [Abstract] [PDF]
|
|
|
|
 |
|
 A Achiron, M Polliack, S M Rao, Y Barak, M Lavie, N Appelboim, and Y Harel Cognitive patterns and progression in multiple sclerosis: construction and validation of percentile curves J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 744 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M S A Deloire, E Salort, M Bonnet, Y Arimone, M Boudineau, H Amieva, B Barroso, J-C Ouallet, C Pachai, E Galliaud, et al. Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis J. Neurol. Neurosurg. Psychiatry, April 1, 2005; 76(4): 519 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Salminen, R. I. Portin, A. Koskinen, H. Helenius, and M. Nurmi Associations between Serum Testosterone Fall and Cognitive Function in Prostate Cancer Patients Clin. Cancer Res., November 15, 2004; 10(22): 7575 - 7582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Archibald, X. Wei, J. N. Scott, C. J. Wallace, Y. Zhang, L. M. Metz, and J. R. Mitchell Posterior fossa lesion volume and slowed information processing in multiple sclerosis Brain, July 1, 2004; 127(7): 1526 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gadea, M. C. Martinez-Bisbal, L. Marti-Bonmati, R. Espert, B. Casanova, F. Coret, and B. Celda Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosis Brain, January 1, 2004; 127(1): 89 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M R Piras, I Magnano, E D G Canu, K S Paulus, W M Satta, A Soddu, M Conti, A Achene, G Solinas, and I Aiello Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 878 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Amato, G. Ponziani, G. Siracusa, and S. Sorbi Cognitive Dysfunction in Early-Onset Multiple Sclerosis: A Reappraisal After 10 Years Arch Neurol, October 1, 2001; 58(10): 1602 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Karussis, H. L Weiner, and O. Abramsky Multiple sclerosis vs Lyme disease: A case presentation to a discussant and a review of the literature Multiple Sclerosis, December 1, 1999; 5(6): 395 - 402. [PDF]
|
|
|
|
|
|
W. W Beatty Assessment of cognitive and psychological functions in patients with multiple sclerosis: considerations for databasing Multiple Sclerosis, August 1, 1999; 5(4): 239 - 243. [Abstract] [PDF]
|
|
|
|
|
|
G Comi, V Martinelli, T Locatelli, L Leocani, and S Medaglini Neurophysiological and cognitive markers of disease evolution in multiple sclerosis Multiple Sclerosis, June 1, 1998; 4(3): 260 - 265. [Abstract] [PDF]
|
|