Brain, Vol 120, Issue 2 327-337, Copyright © 1997 by Oxford University Press
D Timmann and FB Horak
We reported previously that patients with cerebellar deficits were unable
to scale the magnitude of their early automatic postural responses to the
predicted amplitudes of surface translations based on central set from
prior experience. The present study investigated whether this deficit in
set-dependent amplitude scaling was based predominantly on the cerebellar
patient's disability (i) to predict perturbation amplitudes on the basis of
prior experience, (ii) to scale the gain or magnitude of upcoming postural
responses or (iii) to habituate postural responses. The increase in size of
the early postural response when a larger than actual platform amplitude
was expected and decrease when a smaller one was expected was defined as a
measure of set-dependent amplitude prediction. The suppression of the
postural response when the same platform velocity was repeated was used as
a measure of habituation. The correlation between the size of early
postural responses and platform amplitudes when presented serially, but not
randomly, tested the ability to scale the gain of postural responses based
on prior experience. Results show that although cerebellar patients could
predict perturbation amplitudes based on prior experience, they could not
use this prediction to modify precisely the gain of responses. The ability
to habituate the magnitude of postural responses was not affected by
cerebellar lesions. Thus, the cerebellum might not be critical for
predicting upcoming events or for habituating to repeated postural stimuli,
although it is important for accurate tuning of response gain based on
prediction.
ARTICLES
Prediction and set-dependent scaling of early postural responses in cerebellar patients
R. S. Dow Neurological Sciences Institute, Portland, OR 97209, USA.
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