Brain, Vol 120, Issue 6 1085-1096, Copyright © 1997 by Oxford University Press
AJ Thompson, CH Polman, DH Miller, WI McDonald, B Brochet, X Filippi M Montalban and J De Sa
Patients with multiple sclerosis who develop progressive disability from
onset without relapses or remissions pose difficulties in diagnosis,
monitoring of disease activity and treatment. There is a need to define the
diagnostic criteria for this group more precisely and, in particular, to
describe a comprehensive battery of investigations to exclude other
conditions. The mechanisms underlying the development of disability and the
role of MRI in monitoring disease activity in this clinical subgroup
require elucidation, particularly in view of the lack of change on
conventional imaging in the presence of continuing clinical deterioration.
The prognosis is poor and there are currently no treatment trials for this
form of the disease.
REVIEWS
Primary progressive multiple sclerosis
Department of Clinical Neurology, Institute of Neurology, London, UK.
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M. Filippi, C. Tortorella, and M. Bozzali Normal-appearing white matter changes in multiple sclerosis: the contribution of magnetic resonance techniques Multiple Sclerosis, August 1, 1999; 5(4): 273 - 282. [Abstract] [PDF]
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G. Mastronardo, M. A. Rocca, G. Iannucci, C. Pereira, and M. Filippi A Longitudinal MR Study of the Presymptomatic Phase in a Patient with Clinically Definite Multiple Sclerosis AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1268 - 1272. [Abstract] [Full Text]
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F. Fazekas, F. Barkhof, M. Filippi, R. I. Grossman, D. K. B. Li, W. I. McDonald, H. F. McFarland, D. W. Paty, J. H. Simon, J. S. Wolinsky, et al. The contribution of magnetic resonance imaging to the diagnosis of multiple sclerosis Neurology, August 1, 1999; 53(3): 448 - 448. [Abstract] [Full Text] [PDF]
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S. J. Camp, V. L. Stevenson, A. J. Thompson, D. H. Miller, C. Borras, S. Auriacombe, B. Brochet, M. Falautano, M. Filippi, L. Herisse-Dulo, et al. Cognitive function in primary progressive and transitional progressive multiple sclerosis: A controlled study with MRI correlates Brain, July 1, 1999; 122(7): 1341 - 1348. [Abstract] [Full Text] [PDF]
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D. A. Cottrell, M. Kremenchutzky, G. P. A. Rice, W. Hader, J. Baskerville, and G. C. Ebers The natural history of multiple sclerosis: a geographically based study: 6. Applications to planning and interpretation of clinical therapeutic trials in primary progressive multiple sclerosis Brain, April 1, 1999; 122(4): 641 - 647. [Abstract] [Full Text] [PDF]
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V. L. Stevenson, D. H. Miller, M. Rovaris, F. Barkhof, B. Brochet, V. Dousset, V. Dousset, M. Filippi, X. Montalban, C. H. Polman, et al. Primary and transitional progressive MS: A clinical and MRI cross-sectional study Neurology, March 1, 1999; 52(4): 839 - 839. [Abstract] [Full Text] [PDF]
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M. Filippi, G. Iannucci, C. Tortorella, L. Minicucci, M. A. Horsfield, B. Colombo, M. P. Sormani, and G. Comi Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI Neurology, February 1, 1999; 52(3): 588 - 588. [Abstract] [Full Text] [PDF]
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G Giovannoni, A J. Green, and E J Thompson Are there any body fluid markers of brain atrophy in multiple sclerosis? Multiple Sclerosis, June 1, 1998; 4(3): 138 - 142. [Abstract] [PDF]
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G V McDonnell and S A Hawkins Clinical study of primary progressive multiple sclerosis in Northern Ireland, UK J. Neurol. Neurosurg. Psychiatry, April 1, 1998; 64(4): 451 - 454. [Abstract] [Full Text] [PDF]
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