Brain, Vol 120, Issue 8 1485-1508, Copyright © 1997 by Oxford University Press
HW Moser
The occasion of the presentation of the eighth Gordon Holmes Lecture left
me feeling both honoured and awed, as a result of my review of the Selected
Papers of Gordon Holmes (Phillips CG: Selected Papers of Gordon Holmes,
compiled and edited for the Guarantors of Brain. Oxford University Press,
1979), kindly presented to me by the sponsors of the meeting. This volume
lists 174 publications produced over a 55-year period, and contains
reprints of contributions to neuroanatomy, neuropathology, and to disorders
that affected the adrenal cortex, the spinal cord, the cerebellum and the
cerebral cortex. Yet I also feel a sense of sadness; the invitation to
present the lecture came from the late Anita Harding who, such a short time
before her illness, gave me personal guidance and encouragement. In this
lecture I endeavour to follow the example of Gordon Holmes, namely the
stepwise analysis of a clinical problem, first by observation of the
patient, followed by the application of techniques that can clarify it,
leading to new knowledge not only about the specific disorder, but also
about the nervous system and human biology in general and, it is to be
hoped, to more effective therapy.
REVIEWS
Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy
Kennedy Krieger Institute, Baltimore, MD 21205, USA.
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