Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (115)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Scolding, N.
Right arrow Articles by Newcombe, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scolding, N.
Right arrow Articles by Newcombe, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol 121, Issue 12 2221-2228, Copyright © 1998 by Oxford University Press

ARTICLES

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

N Scolding, R Franklin, S Stevens, CH Heldin, A Compston and J Newcombe
MRC Cambridge Centre for Brain Repair, University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK.

In multiple sclerosis, partial remyelination is conspicuous in many lesions, but widespread and lasting myelin repair ultimately fails as disability and handicap accumulate. Thus far, the precise identity of the cell responsible for limited spontaneous myelin repair has remained obscure. In the rodent, the proliferative oligodendrocyte progenitor is the most efficient remyelinating cell; this has now been identified in cultures prepared from normal human brain, but has proved difficult to demonstrate in situ. We adapted techniques using antibodies against the human platelet-derived growth factor-alpha receptor to identify oligodendrocyte progenitors in human tissue sections. Small numbers of oligodendrocyte progenitors were found in normal adult human white matter. Progenitors were also demonstrable in acute and chronic lesions from patients dying with multiple sclerosis, but with no evidence of any marked reactive increase in cell numbers. Understanding the biology of the remyelinating cell, and in particular the reason for its apparent failure to repopulate demyelinated lesions, is important for the development of remyelination treatments.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
P. He and Y. Shen
Interruption of {beta}-Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease
J. Neurosci., May 20, 2009; 29(20): 6545 - 6557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. M. Omari, S. E. Lutz, L. Santambrogio, S. A. Lira, and C. S. Raine
Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1
Am. J. Pathol., January 1, 2009; 174(1): 164 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. Chandran, D. Hunt, A. Joannides, C. Zhao, A. Compston, and R. J.M Franklin
Myelin repair: the role of stem and precursor cells in multiple sclerosis
Phil Trans R Soc B, January 12, 2008; 363(1489): 171 - 183.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-Q. Liu, J. W. Carl Jr, P. S. Joshi, A. RayChaudhury, X.-A. Pu, F.-D. Shi, and X.-F. Bai
CD24 on the Resident Cells of the Central Nervous System Enhances Experimental Autoimmune Encephalomyelitis
J. Immunol., May 15, 2007; 178(10): 6227 - 6235.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Nait-Oumesmar, N. Picard-Riera, C. Kerninon, L. Decker, D. Seilhean, G. U. Hoglinger, E. C. Hirsch, R. Reynolds, and A. Baron-Van Evercooren
Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors
PNAS, March 13, 2007; 104(11): 4694 - 4699.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
S. A Goldman and M. S Windrem
Cell replacement therapy in neurological disease
Phil Trans R Soc B, September 29, 2006; 361(1473): 1463 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Assanah, R. Lochhead, A. Ogden, J. Bruce, J. Goldman, and P. Canoll
Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.
J. Neurosci., June 21, 2006; 26(25): 6781 - 6790.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. M. Frohman, M. K. Racke, and C. S. Raine
Multiple sclerosis--the plaque and its pathogenesis.
N. Engl. J. Med., March 2, 2006; 354(9): 942 - 955.
[Full Text] [PDF]

Home page
 BrainHome page
K. M. Omari, G. R. John, S. C. Sealfon, and C. S. Raine
CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis
Brain, May 1, 2005; 128(5): 1003 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. Ruffini, N. Arbour, M. Blain, A. Olivier, and J. P. Antel
Distinctive Properties of Human Adult Brain-Derived Myelin Progenitor Cells
Am. J. Pathol., December 1, 2004; 165(6): 2167 - 2175.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. Peters and C. Sethares
Oligodendrocytes, their Progenitors and other Neuroglial Cells in the Aging Primate Cerebral Cortex
Cereb Cortex, September 1, 2004; 14(9): 995 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. F. Stidworthy, S. Genoud, W.-W. Li, D. P. Leone, N. Mantei, U. Suter, and R. J. M. Franklin
Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination
Brain, September 1, 2004; 127(9): 1928 - 1941.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. L. Mason, A. Toews, J. D. Hostettler, P. Morell, K. Suzuki, J. E. Goldman, and G. K. Matsushima
Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions
Am. J. Pathol., May 1, 2004; 164(5): 1673 - 1682.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
O. Lily, J. Palace, and A. Vincent
Serum autoantibodies to cell surface determinants in multiple sclerosis: a flow cytometric study
Brain, February 1, 2004; 127(2): 269 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. Imitola, E. Y. Snyder, and S. J. Khoury
Genetic programs and responses of neural stem/progenitor cells during demyelination: potential insights into repair mechanisms in multiple sclerosis
Physiol Genomics, August 15, 2003; 14(3): 171 - 197.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Penderis, S. A. Shields, and R. J. M. Franklin
Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system
Brain, June 1, 2003; 126(6): 1382 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. C. Armstrong, T. Q. Le, E. E. Frost, R. C. Borke, and A. C. Vana
Absence of Fibroblast Growth Factor 2 Promotes Oligodendroglial Repopulation of Demyelinated White Matter
J. Neurosci., October 1, 2002; 22(19): 8574 - 8585.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Picard-Riera, L. Decker, C. Delarasse, K. Goude, B. Nait-Oumesmar, R. Liblau, D. Pham-Dinh, and A. B.-V. Evercooren
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
PNAS, October 1, 2002; 99(20): 13211 - 13216.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
D M Chari and W F Blakemore
New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation
Multiple Sclerosis, August 1, 2002; 8(4): 271 - 277.
[Abstract] [PDF]

Home page
 BrainHome page
G. Wolswijk
Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord
Brain, February 1, 2002; 125(2): 338 - 349.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Chang, W. W. Tourtellotte, R. Rudick, and B. D. Trapp
Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
N. Engl. J. Med., January 17, 2002; 346(3): 165 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
D. Prayer, A. J. Barkovich, D. A. Kirschner, L. M. Prayer, T. P.L. Roberts, J. Kucharczyk, and M. E. Moseley
Visualization of Nonstructural Changes in Early White Matter Development on Diffusion-Weighted MR Images: Evidence Supporting Premyelination Anisotropy
AJNR Am. J. Neuroradiol., September 1, 2001; 22(8): 1572 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
N. De Stefano, S. Narayanan, G. S. Francis, R. Arnaoutelis, M. C. Tartaglia, J. P. Antel, P. M. Matthews, and D. L. Arnold
Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability
Arch Neurol, January 1, 2001; 58(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Jasmin, G. Janni, T. M. Moallem, D. A. Lappi, and P. T. Ohara
Schwann Cells Are Removed from the Spinal Cord after Effecting Recovery from Paraplegia
J. Neurosci., December 15, 2000; 20(24): 9215 - 9223.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Chang, A. Nishiyama, J. Peterson, J. Prineas, and B. D. Trapp
NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions
J. Neurosci., September 1, 2000; 20(17): 6404 - 6412.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
G. Wolswijk
Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
Brain, January 1, 2000; 123(1): 105 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. S. Roy, S. Wang, C. Harrison-Restelli, A. Benraiss, R. A. R. Fraser, M. Gravel, P. E. Braun, and S. A. Goldman
Identification, Isolation, and Promoter-Defined Separation of Mitotic Oligodendrocyte Progenitor Cells from the Adult Human Subcortical White Matter
J. Neurosci., November 15, 1999; 19(22): 9986 - 9995.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Dowling, X. Ming, S. Raval, W. Husar, P. Casaccia-Bonnefil, M. Chao, S. Cook, and B. Blumberg
Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques
Neurology, November 1, 1999; 53(8): 1676 - 1676.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Calza, M. Fernandez, A. Giuliani, L. Aloe, and L. Giardino
Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis
PNAS, March 5, 2002; 99(5): 3258 - 3263.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.