Brain, Vol 121, Issue 2 191-203, Copyright © 1998 by Oxford University Press
TD Griffiths, T Sigmundsson, N Takei, D Rowe and RM Murray
Neurological assessment was carried out on patients with schizophrenia from
multiply and singly affected families, their relatives, and a normal
control group (214 subjects). A systematic examination was used in which
abnormal signs were divided into 'primary' and 'integrative' signs. Primary
signs were elicited by a standard clinical neurological examination and
included signs of focal damage to nuclei and tracts, whilst integrative
signs were selected as reflecting distributed brain function. The
assessments were carried out to test the hypotheses that (i) neurological
abnormalities are present in schizophrenia, (ii) the pattern of abnormality
is different in familial and sporadic schizophrenic subjects, and (iii) the
well relatives of familial (but not sporadic) schizophrenic subjects will
show neurological abnormalities. An excess of primary signs compared with
the controls was demonstrated in the sporadic schizophrenic group only.
Both the familial schizophrenics and their first-degree relatives (but not
their sporadic counterparts) showed an increase in integrative signs. The
results support the existence of different mechanisms of underlying brain
dysfunction in familial and sporadic schizophrenia.
ARTICLES
Neurological abnormalities in familial and sporadic schizophrenia
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. C. K. Chan, T. Xu, R. W. Heinrichs, Y. Yu, and Y. Wang Neurological Soft Signs in Schizophrenia: A Meta-analysis Schizophr Bull, April 17, 2009; (2009) sbp011v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dazzan, T. Lloyd, K. D. Morgan, J. Zanelli, C. Morgan, K. Orr, G. Hutchinson, P. Fearon, M. Allin, L. Rifkin, et al. Neurological abnormalities and cognitive ability in first-episode psychosis The British Journal of Psychiatry, September 1, 2008; 193(3): 197 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dazzan, K. D. Morgan, X. Chitnis, J. Suckling, C. Morgan, P. Fearon, P. K. McGuire, P. B. Jones, J. Leff, and R. M. Murray The Structural Brain Correlates of Neurological Soft Signs in Healthy Individuals Cereb Cortex, August 1, 2006; 16(8): 1225 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Barkus, J. Stirling, R. Hopkins, and S. Lewis The Presence of Neurological Soft Signs Along the Psychosis Proneness Continuum Schizophr Bull, July 1, 2006; 32(3): 573 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Allin, M Rooney, T Griffiths, M Cuddy, J Wyatt, L Rifkin, and R Murray Neurological abnormalities in young adults born preterm J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 495 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bombin, C. Arango, and R. W Buchanan Significance and Meaning of Neurological Signs in Schizophrenia: Two Decades Later Schizophr Bull, October 1, 2005; 31(4): 962 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Honer, L. C. Kopala, and J. Rabinowitz Extrapyramidal symptoms and signs in first-episode, antipsychotic exposed and non-exposed patients with schizophrenia or related psychotic illness J Psychopharmacol, May 1, 2005; 19(3): 277 - 285. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Dazzan, K. D. Morgan, K. G. Orr, G. Hutchinson, X. Chitnis, J. Suckling, P. Fearon, J. Salvo, P. K. McGuire, R. M. Mallett, et al. The structural brain correlates of neurological soft signs in AeSOP first-episode psychoses study Brain, January 1, 2004; 127(1): 143 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Keshavan, R. D. Sanders, J. A. Sweeney, V. A. Diwadkar, G. Goldstein, J. W. Pettegrew, and N. R. Schooler Diagnostic Specificity and Neuroanatomical Validity of Neurological Abnormalities in First-Episode Psychoses Am J Psychiatry, July 1, 2003; 160(7): 1298 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Seidman, S. V. Faraone, J. M. Goldstein, W. S. Kremen, N. J. Horton, N. Makris, R. Toomey, D. Kennedy, V. S. Caviness, and M. T. Tsuang Left Hippocampal Volume as a Vulnerability Indicator for Schizophrenia: A Magnetic Resonance Imaging Morphometric Study of Nonpsychotic First-Degree Relatives Arch Gen Psychiatry, September 1, 2002; 59(9): 839 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. DAZZAN and R. M. MURRAY Neurological soft signs in first-episode psychosis: a systematic review The British Journal of Psychiatry, September 1, 2002; 181 (43): s50 - s57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Egan, T. M. Hyde, J. B. Bonomo, V. S. Mattay, L. B. Bigelow, T. E. Goldberg, and D. R. Weinberger Relative Risk of Neurological Signs in Siblings of Patients With Schizophrenia Am J Psychiatry, November 1, 2001; 158(11): 1827 - 1834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cannon, P. Jones, M. O. Huttunen, A. Tanskanen, T. Huttunen, S. Rabe-Hesketh, and R. M. Murray School Performance in Finnish Children and Later Development of Schizophrenia: A Population-Based Longitudinal Study Arch Gen Psychiatry, May 1, 1999; 56(5): 457 - 463. [Abstract] [Full Text] [PDF]
|
|