Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (29)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Terwindt, G. M.
Right arrow Articles by Ferrari, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Terwindt, G. M.
Right arrow Articles by Ferrari, M. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Brain, Vol 121, Issue 2 303-316, Copyright © 1998 by Oxford University Press

ARTICLES

Clinical and genetic analysis of a large Dutch family with autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon

GM Terwindt, J Haan, RA Ophoff, SM Groenen, CW Storimans, JB Lanser, RA Roos, EM Bleeker-Wagemakers, RR Frants and MD Ferrari
Department of Neurology, Leiden University Medical Centre, The Netherlands.

We describe an extended Dutch family with a new hereditary disorder: autosomal dominant vascular retinopathy, migraine and Raynaud's phenomenon. Information was obtained on 289 family members (151 males, 138 females), of whom 198 were personally interviewed. Retinopathy was found in 20 (6.9%) of the family members, migraine in 65 (22.5%) and Raynaud's phenomenon in 50 (17.3%). A combination of all three symptoms was found in 11 subjects. In a genetic linkage analysis we firstly excluded several candidate loci. Subsequently, 75% of the autosomal genome was excluded in a genome-wide search. The following conclusions were drawn. First, genetic factors are involved in Raynaud's phenomenon. Secondly, the genetic linkage of migraine with vascular retinopathy and Raynaud's phenomenon supports a vascular aetiology of this disorder. Finding the gene for this family may help to elucidate the genetic background of migraine and of vascular disorders in general.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NeurologyHome page
F. H. Vanmolkot, L. M. Van Bortel, and J. N. de Hoon
Altered arterial function in migraine of recent onset
Neurology, May 8, 2007; 68(19): 1563 - 1570.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
W. C. Low, M. Junna, A. Borjesson-Hanson, C. M. Morris, T. H. Moss, D. L. Stevens, D. St Clair, T. Mizuno, W. W. Zhang, K. Mykkanen, et al.
Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL
Brain, February 1, 2007; 130(2): 357 - 367.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Z. Cader, J. L. Steckley, D. A. Dyment, R. S. McLachlan, and G. C. Ebers
A genome-wide screen and linkage mapping for a large pedigree with episodic ataxia
Neurology, July 12, 2005; 65(1): 156 - 158.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M.-G. Bousser
Estrogens, Migraine, and Stroke
Stroke, November 1, 2004; 35(11_suppl_1): 2652 - 2656.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. D. Mitsikostas, P. P. Sfikakis, and P. J. Goadsby
A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth
Brain, May 1, 2004; 127(5): 1200 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Vahedi, P. Massin, J.-P. Guichard, S. Miocque, M. Polivka, F. Goutieres, D. Dress, F. Chapon, M.-M. Ruchoux, F. Riant, et al.
Hereditary infantile hemiparesis, retinal arteriolar tortuosity, and leukoencephalopathy
Neurology, January 14, 2003; 60(1): 57 - 63.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. P. Dreier, J. Kleeberg, G. Petzold, J. Priller, O. Windmuller, H.-D. Orzechowski, U. Lindauer, U. Heinemann, K. M. Einhaupl, and U. Dirnagl
Endothelin-1 potently induces Leao's cortical spreading depression in vivo in the rat: A model for an endothelial trigger of migrainous aura?
Brain, January 1, 2002; 125(1): 102 - 112.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.