Brain, Vol 121, Issue 4 717-724, Copyright © 1998 by Oxford University Press
S Knecht, H Henningsen, C Hohling, T Elbert, H Flor, C Pantev and E Taub
We report a follow-up study on seven arm amputees in whom magnetic source
imaging had originally revealed a strong correlation between the amount of
cortical invasion of the deafferented cortex and the amount of pain evoked
sensation mislocalized to the phantom limb. This re- examination was
performed in order to corroborate the phenomenon of mislocalization. On
follow-up examination for mislocalization 4 weeks later, a close
correlation had remained between the original amount of cortical
representational reorganization of the amputation zone (at the first
examination) and the number of sites from where painful stimuli evoked
sensations referred to the phantom limb, i.e. the amount of perceptual
mislocalization, at the second examination. However, contrary to our
expectation, the topography of referred sensation had completely changed in
every patient. These results suggest that while the overall extent of
reorganization is a rather stable phenomenon, the concomitant changes in
the pattern of sensory processing are not. This may be due to the fact that
alterations of sensory processing are not hardwired, but are rather
mediated by an extensive and interconnected neural network with fluctuating
synaptic strengths. This mechanism may be of importance for neurological
rehabilitation.
ARTICLES
Plasticity of plasticity? Changes in the pattern of perceptual correlates of reorganization after amputation
Department of Neurology, University of Munster, Germany.
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